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|a 10.3760/cma.j.cn112140-20231115-00370
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|a chi
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|a Li, S R
|e verfasserin
|4 aut
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|a Related factors of acute symptomatic seizures and epilepsy in children with myelin oligodendrocyte glycoprotein antibody-associated disease
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 02.07.2024
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|a Date Revised 24.07.2024
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|a published: Print
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|a Citation Status MEDLINE
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|a Objective: To investigate the risk factors of acute symptomatic seizures (ASS) and epilepsy in children with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods: A ambispective cohort study was used including 74 children with MOGAD who were admitted to the Department of Pediatrics of Peking University First Hospital from January 2013 to June 2023 and were followed up. Demographic information, clinical information, treatment status, ASS and epilepsy status were collected. The clinical phenotypes were classified. According to the presence or absence of ASS in the course of disease, the children and the course of disease were divided into groups with and without ASS. Chi-square test, Fisher exact test and Mann Whitney U test were used to analyze the correlation between symptoms and auxiliary examination characteristics and the occurrence of ASS in the two groups of children. Multivariate Logistic regression analysis was used for multivariate analysis. Results: The onset age of the 74 children with MOGAD was 6.58 (3.80, 9.67) years, including 38 females (51.4%) and 36 males (48.6%). The duration of the final follow-up was 2.67 (1.10, 4.12) years, with a total of 239 times acute clinical episodes. ASS occurred in 39.2% (29/74) children during the course of disease and in 29.3% (70/239) of attacks. The common phenotypes were ADEM (67 times (28.0%)), optic neuritis (37 times (15.4%)) and cerebral cortical encephalitis (31 times (13.0%)) in 239 times acute clinical episodes. The incidence of ASS in ADEM and cerebral cortical encephalitis phenotype was 28.4%(19/67) and 100.0% (31/31), respectively. Multivariate analysis showed that cortical involvement on magnetic resonance imaging during clinical attacks was an independent risk factor for ASS (β=-1.49, OR=0.23) after excluding attacks involving only optic nerve or spinal cord (49 episodes). During the follow-up, 5 children (6.8%) had epilepsy, and all children with epilepsy had multiple clinical attacks of MOGAD and previous ASS. Conclusions: Cortical involvement on magnetic resonance imaging during clinical episodes is an independent risk factor for ASS in children with MOGAD. All MOGAD children with epilepsy had ASS and multiple MOGAD clinical episodes in the past
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|a English Abstract
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|a Journal Article
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|a Myelin-Oligodendrocyte Glycoprotein
|2 NLM
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|a Autoantibodies
|2 NLM
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| 700 |
1 |
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|a Chang, X T
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|a Zhang, J
|e verfasserin
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|a Teng, X L
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|a Wu, Y
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| 773 |
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|t Zhonghua er ke za zhi = Chinese journal of pediatrics
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|g 62(2024), 7 vom: 02. Juli, Seite 655-660
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|g year:2024
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|g pages:655-660
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|u http://dx.doi.org/10.3760/cma.j.cn112140-20231115-00370
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