Sequential breakdown of the Cf-9 leaf mould resistance locus in tomato by Fulvia fulva

Bibliographische Detailangaben
Veröffentlicht in:	The New phytologist. - 1979. - 243(2024), 4 vom: 01. Juli, Seite 1522-1538
1. Verfasser:	de la Rosa, Silvia (VerfasserIn)
Weitere Verfasser:	Schol, Christiaan R, Ramos Peregrina, Ángeles, Winter, David J, Hilgers, Anne M, Maeda, Kazuya, Iida, Yuichiro, Tarallo, Mariana, Jia, Ruifang, Beenen, Henriek G, Rocafort, Mercedes, de Wit, Pierre J G M, Bowen, Joanna K, Bradshaw, Rosie E, Joosten, Matthieu H A J, Bai, Yuling, Mesarich, Carl H
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	The New phytologist
Schlagworte:	Journal Article Avr9 and Avr9B avirulence effector genes Cf‐9 locus Cf‐9C and Cf‐9B resistance genes Fulvia fulva (Cladosporium fulvum) Solanum lycopersicum (tomato) fungus sequential resistance breakdown tomato leaf mould disease Fungal Proteins Plant Proteins

Beschreibung
Zusammenfassung:	© 2024 The Authors. New Phytologist © 2024 New Phytologist Foundation. Leaf mould, caused by Fulvia fulva, is a devastating disease of tomato plants. In many commercial tomato cultivars, resistance to this disease is governed by the Cf-9 locus, which encodes five paralogous receptor-like proteins. Two of these proteins confer resistance: Cf-9C recognises the previously identified F. fulva effector Avr9 and provides resistance during all plant growth stages, while Cf-9B recognises the yet-unidentified F. fulva effector Avr9B and provides mature plant resistance only. In recent years, F. fulva strains have emerged that can overcome the Cf-9 locus, with Cf-9C circumvented through Avr9 deletion. To understand how Cf-9B is circumvented, we set out to identify Avr9B. Comparative genomics, transient expression assays and gene complementation experiments were used to identify Avr9B, while gene sequencing was used to assess Avr9B allelic variation across a world-wide strain collection. A strict correlation between Avr9 deletion and resistance-breaking mutations in Avr9B was observed in strains recently collected from Cf-9 cultivars, whereas Avr9 deletion but no mutations in Avr9B were observed in older strains. This research showcases how F. fulva has evolved to sequentially break down the Cf-9 locus and stresses the urgent need for commercial tomato cultivars that carry novel, stacked resistance genes active against this pathogen
Beschreibung:	Date Completed 18.07.2024 Date Revised 19.07.2024 published: Print-Electronic RefSeq: EF104527.1, KX943086.1, KNG51100.1, KAF7194657.1 Citation Status MEDLINE
ISSN:	1469-8137
DOI:	10.1111/nph.19925