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NLM374058210 |
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240626s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2024.110282
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n1479.xml
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|a (DE-627)NLM374058210
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|a (NLM)38917928
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|a (PII)S1521-6616(24)00391-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Giannakopoulos, Bill
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Domain 5 of Beta 2 glycoprotein I
|b Friend or foe in health? Context matters
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1 |
|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 19.07.2024
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|a Date Revised 22.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Crown Copyright © 2024. Published by Elsevier Inc. All rights reserved.
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|a Beta 2 glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome, an autoimmune disorder characterized by thrombotic and obstetric complications. The autoantibodies that target beta 2 glycoprotein I are pathogenic and contribute to disease pathogenesis. The β2GPI molecule is composed of 5 domains that are numbered 1 through to 5. Autoantibodies bind mainly to domain 1 whereas the majority of the biological functions of the β2GPI molecule in diverse processes such as apoptotic cell clearance, complement regulation, lipopolysaccharide clearance and anticoagulation have been localised to domain 5 and its unique biochemistry, reviewed in this article. The role of purified domain 5 peptide as a potential therapeutic agent in APS and ischemia reperfusion injury is discussed
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| 650 |
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|a Journal Article
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|a Review
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|a Antiphospholipid syndrome
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| 650 |
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4 |
|a Beta 2 glycoprotein I
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| 650 |
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4 |
|a Domain 5
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| 650 |
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4 |
|a Ischemia-reperfusion injury
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| 650 |
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4 |
|a Thrombosis
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| 650 |
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7 |
|a beta 2-Glycoprotein I
|2 NLM
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Autoantigens
|2 NLM
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| 700 |
1 |
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|a Krilis, Steven A
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 265(2024) vom: 27. Juli, Seite 110282
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:265
|g year:2024
|g day:27
|g month:07
|g pages:110282
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2024.110282
|3 Volltext
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