Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis

Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 265(2024) vom: 01. Aug., Seite 110291
Auteur principal: Wang, Tianyu (Auteur)
Autres auteurs: Li, Lichen, Cao, Shan, Sun, Lele, Yu, Gongqi, Xia, Qianqian, Liu, Tingting, Zhao, Qing, Wang, Zhenzhen, Wang, Chuan, Yang, Baoqi, Liu, Yongxia, Chen, Xuechao, Chen, Shengli, Zhou, Guizhi, Liu, Hong, Sun, Yonghu, Zhang, Furen
Format: Article en ligne
Langue:English
Publié: 2024
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Dermatitis herpetiformis Linear IgA bullous dermatosis NADPH NCF2 Neutrophil Proteomics Biomarkers Proteome Immunoglobulin A
Description
Résumé:Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
Linear IgA bullous dermatosis (LABD) and dermatitis herpetiformis (DH) represent the major subtypes of IgA mediated autoimmune bullous disorders. We sought to understand the disease etiology by using serum proteomics. We assessed 92 organ damage biomarkers in LABD, DH, and healthy controls using the Olink high-throughput proteomics. The positive proteomic serum biomarkers were used to correlate with clinical features and HLA type. Targeted proteomic analysis of IgA deposition bullous disorders vs. controls showed elevated biomarkers. Further clustering and enrichment analyses identified distinct clusters between LABD and DH, highlighting the involvement of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Comparative analysis revealed biomarkers with distinction between LABD and DH and validated in the skin lesion. Finally, qualitative correlation analysis with DEPs suggested six biomarkers (NBN, NCF2, CAPG, FES, BID, and PXN) have better prognosis in DH patients. These findings provide potential biomarkers to differentiate the disease subtype of IgA deposition bullous disease
Description:Date Completed 19.07.2024
Date Revised 22.07.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110291