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|a 10.1016/j.clim.2024.110283
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|a eng
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|a Soul, J
|e verfasserin
|4 aut
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|a Tissue gene expression profiles and communication networks inform candidate blood biomarker identification in psoriasis and atopic dermatitis
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|c 2024
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|a Text
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|a Date Completed 19.07.2024
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|a Date Revised 19.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
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|a Overlapping clinical and pathomechanistic features can complicate the diagnosis and treatment of inflammatory skin diseases, including psoriasis and atopic dermatitis (AD). Spatial transcriptomics allows the identification of disease- and cell-specific molecular signatures that may advance biomarker development and future treatments. This study identified transcriptional signatures in keratinocytes and sub-basal CD4+ and CD8+ T lymphocytes from patients with psoriasis and AD. In silico prediction of ligand:receptor interactions delivered key signalling pathways (interferon, effector T cells, stroma cell and matrix biology, neuronal development, etc.). Targeted validation of selected transcripts, including CCL22, RELB, and JUND, in peripheral blood T cells suggests the chosen approach as a promising tool also in other inflammatory diseases. Psoriasis and AD are characterized by transcriptional dysregulation in T cells and keratinocytes that may be targeted therapeutically. Spatial transcriptomics is a valuable tool in the search for molecular signatures that can be used as biomarkers and/or therapeutic targets
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|a Journal Article
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|a Atopic dermatitis
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| 650 |
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|a Bioinformatic
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| 650 |
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|a Biomarker
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| 650 |
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|a Inflammation
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| 650 |
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|a Psoriasis
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| 650 |
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|a Spatial transcriptomics
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| 650 |
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|a Treatment
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| 650 |
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|a Biomarkers
|2 NLM
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|a Carlsson, E
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|a Hofmann, S R
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|a Russ, S
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| 700 |
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|a Hawkes, J
|e verfasserin
|4 aut
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|a Schulze, F
|e verfasserin
|4 aut
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| 700 |
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|a Sergon, M
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|4 aut
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| 700 |
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|a Pablik, J
|e verfasserin
|4 aut
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|a Abraham, S
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|a Hedrich, C M
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
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|g 265(2024) vom: 01. Aug., Seite 110283
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