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240616s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110284
|2 doi
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|a pubmed25n1244.xml
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|a (DE-627)NLM373668686
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|a (NLM)38878808
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|a (PII)S1521-6616(24)00393-0
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|a DE-627
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|c DE-627
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|a eng
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|a Zhu, Litong
|e verfasserin
|4 aut
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|a Alterations in exhausted and classical memory B cells in lupus nephritis - Relationship with disease relapse
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 19.07.2024
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|a Date Revised 19.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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|a INTRODUCTION: B cell exhaustion is a functional abnormality of B lymphocytes observed in chronic infections and shows association with autoreactivity. The role of exhausted and classical memory B cells in maintaining disease stability of lupus nephritis (LN) remains unclear
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|a METHODS: We measured classical memory (CD19+CD21+CD27+), exhausted B cells (CD19+CD21-CD27-), and related cytokines in LN patients with multiple relapses (MR) (n = 15) and no relapse (NR) (n = 15) during disease remission. The expression of inhibitory/adhesion molecules, cell proliferation and calcium mobilization in classical memory and exhausted B cells were also assessed
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|a RESULTS: The MR group had higher proportion of circulating exhausted and classical memory B cells compared to the NR group and healthy controls (HC) (p all <0.05 for MR vs. NR or HC). Blood levels of IL-6, BAFF, IL-21, CD62L, CXCR3 and Siglec-6 were all higher in the MR group (p < 0.05, for all). Exhausted B cells from the MR group showed higher FcRL4, CD22, CD85j and CD183 but lower CD62L expression than NR and HC groups. Exhausted B cells from MR patients exhibited reduced proliferation compared to NR patients and HC, while classical memory B cell proliferation in MR group was higher than the other two groups. Exhausted B cells from both MR and NR patients showed impaired calcium mobilization
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|a CONCLUSION: Alterations in exhausted and classical memory B cells are related to disease relapse in LN. These findings may help devise new strategies for monitoring disease activity and preventing relapse in LN
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|a Journal Article
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|a Classical memory B cells
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|a Exhausted memory B cells
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|a Lupus nephritis
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|a Relapse
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| 650 |
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|a Cytokines
|2 NLM
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1 |
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|a Wong, Yick Hei
|e verfasserin
|4 aut
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1 |
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|a Wong, Sunny S H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheung, Simon C Y
|e verfasserin
|4 aut
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|a Sher, Jason K H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yam, Irene Y L
|e verfasserin
|4 aut
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| 700 |
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|a Yung, Susan
|e verfasserin
|4 aut
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| 700 |
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|a Chan, Tak Mao
|e verfasserin
|4 aut
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| 700 |
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|a Yap, Desmond Y H
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 265(2024) vom: 25. Aug., Seite 110284
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
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|g volume:265
|g year:2024
|g day:25
|g month:08
|g pages:110284
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|u http://dx.doi.org/10.1016/j.clim.2024.110284
|3 Volltext
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