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20240726232441.0 |
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240608s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202401667
|2 doi
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|a pubmed24n1482.xml
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|a (DE-627)NLM373317050
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|a (NLM)38843541
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhou, Ruyi
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Grooved Microneedle Patch Augments Adoptive T Cell Therapy Against Solid Tumors via Diverting Regulatory T Cells
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| 264 |
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 25.07.2024
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|a Date Revised 25.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a The efficacy of adoptive T cell therapy (ACT) for the treatment of solid tumors remains challenging. In addition to the poor infiltration of effector T (Teff) cells limited by the physical barrier surrounding the solid tumor, another major obstacle is the extensive infiltration of regulatory T (Treg) cells, a major immunosuppressive immune cell subset, in the tumor microenvironment. Here, this work develops a grooved microneedle patch for augmenting ACT, aiming to simultaneously overcome physical and immunosuppressive barriers. The microneedles are engineered through an ice-templated method to generate the grooved structure for sufficient T-cell loading. In addition, with the surface modification of chemokine CCL22, the MNs could not only directly deliver tumor-specific T cells into solid tumors through physical penetration, but also specifically divert Treg cells from the tumor microenvironment to the surface of the microneedles via a cytokine concentration gradient, leading to an increase in the ratio of Teff cells/Treg cells in a mouse melanoma model. Consequently, this local delivery strategy of both T cell receptor T cells and chimeric antigen receptor T cells via the CCL22-modified grooved microneedles as a local niche could significantly enhance the antitumor efficacy and reduce the on-target off-tumor toxicity of ACT
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4 |
|a Journal Article
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4 |
|a Treg cells
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| 650 |
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4 |
|a adoptive T cell therapy
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| 650 |
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4 |
|a cell delivery
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| 650 |
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4 |
|a immunotherapy
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| 650 |
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4 |
|a microneedle
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| 650 |
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7 |
|a Chemokine CCL22
|2 NLM
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| 700 |
1 |
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|a Yu, Hao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sheng, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Yingke
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Yingxin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a You, Jiahuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Yinxian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Bowen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Hongjun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yuqi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Yugang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Zhen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Jicheng
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 30 vom: 30. Juli, Seite e2401667
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
8 |
|g volume:36
|g year:2024
|g number:30
|g day:30
|g month:07
|g pages:e2401667
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202401667
|3 Volltext
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