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20240627232451.0 |
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240525s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110260
|2 doi
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|a pubmed24n1453.xml
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|a (DE-627)NLM372772064
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|a (NLM)38788885
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|a (PII)S1521-6616(24)00369-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Debreceni, Ivy L
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a IL-27 promotes pathogenic T cells in a mouse model of Sjögren's disease
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| 264 |
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1 |
|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.06.2024
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|a Date Revised 27.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Sjögren's disease (SjD) is a chronic autoimmune disease characterized by focal lymphocytic inflammation in lacrimal and salivary glands. We recently identified IL-27 as a requisite signal for the spontaneous SjD-like manifestations in nonobese diabetic (NOD) mice. Here, we define T cell-intrinsic effects of IL-27 in lacrimal gland disease in NOD mice. IL-27 receptor was required by both CD4 T effector (Te) cells and CD8 T cells to mediate focal inflammation. Intrinsic IL-27 signaling was associated with PD-1 and ICOS expressing T follicular helper (Tfh)-like CD4 Te cells within lacrimal glands, including subsets defined by CD73 or CD39 expression. CD8 T cells capable of IL-27 signaling also expressed PD-1 with subsets expressing ICOS and CD73 demonstrating a T follicular cytotoxic (Tfc)-like cell phenotype and others expressing a CD39hi exhausted-like phenotype. These findings suggest IL-27 is a key early signal driving a follicular-type response in lacrimal gland inflammation in NOD mice
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4 |
|a Journal Article
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| 650 |
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4 |
|a Exhausted CD8 T cells
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| 650 |
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4 |
|a IL-27
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| 650 |
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4 |
|a Sjögren's disease
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| 650 |
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4 |
|a T follicular cytotoxic cells
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| 650 |
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4 |
|a T follicular helper cells
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| 650 |
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4 |
|a T peripheral helper cells
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| 650 |
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7 |
|a Il27 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Interleukins
|2 NLM
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| 650 |
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7 |
|a Programmed Cell Death 1 Receptor
|2 NLM
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| 650 |
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7 |
|a Receptors, Interleukin
|2 NLM
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| 650 |
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7 |
|a Interleukin-27
|2 NLM
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| 650 |
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7 |
|a Inducible T-Cell Co-Stimulator Protein
|2 NLM
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| 650 |
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7 |
|a Apyrase
|2 NLM
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| 650 |
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7 |
|a EC 3.6.1.5
|2 NLM
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| 650 |
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7 |
|a Il27ra protein, mouse
|2 NLM
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| 650 |
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7 |
|a Pdcd1 protein, mouse
|2 NLM
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| 700 |
1 |
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|a Barr, Jennifer Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Upton, Ellen M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Yi-Guang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lieberman, Scott M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 264(2024) vom: 24. Juni, Seite 110260
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:264
|g year:2024
|g day:24
|g month:06
|g pages:110260
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2024.110260
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 264
|j 2024
|b 24
|c 06
|h 110260
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