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|a 10.1002/mrc.5448
|2 doi
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|a pubmed24n1489.xml
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|e rakwb
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|a eng
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|a Sager, Emine
|e verfasserin
|4 aut
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|a Hydrogen bond formation may enhance RDC-based discrimination of enantiomers
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 02.08.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2024 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.
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|a The distinction of enantiomers based on residual anisotropic parameters obtained by alignment in chiral poly-γ-benzyl-L-glutamate (PBLG) is among the strongest in high-resolution NMR spectroscopy. However, large variations in enantiodifferentiation among different solutes are frequently observed. One hypothesis is that the formation of hydrogen bonds between solute and PBLG is important for the distinction of enantiomers. With a small set of three almost spherical enantiomeric pairs, for which 1DCH residual dipolar couplings are measured, we address this issue in a systematic way: borneol contains a single functional group that can act as a hydrogen bond donor, camphor has a single group that may act as a hydrogen bond acceptor, and quinuclidinol can act as both hydrogen bond donor and acceptor. The results are unambiguous: although camphor shows low enantiodifferentiation with PBLG and alignment that can be predicted well by the purely steric TRAMITE approach, the distinction of enantiomers for the other enantiomeric pairs is significantly higher with alignment properties that must involve a specific interaction in addition to steric alignment
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|a Journal Article
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|a PBLG
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|a hydrogen bonding
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|a partial alignment
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|a residual dipolar couplings
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|a solute medium interaction
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|a Tzvetkova, Pavleta
|e verfasserin
|4 aut
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|a Lingel, Andreas
|e verfasserin
|4 aut
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|a Gossert, Alvar D
|e verfasserin
|4 aut
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|a Luy, Burkhard
|e verfasserin
|4 aut
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 62(2024), 9 vom: 01. Aug., Seite 639-647
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
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|g volume:62
|g year:2024
|g number:9
|g day:01
|g month:08
|g pages:639-647
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|u http://dx.doi.org/10.1002/mrc.5448
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