Multicenter evaluation of the diagnostic efficacy of jaundice color card for neonatal hyperbilirubinemia

Multicenter evaluation of the diagnostic efficacy of jaundice color card for neonatal hyperbilirubinemia

Objective: To evaluate the diagnostic efficacy and practicality of the Jaundice color card (JCard) as a screening tool for neonatal jaundice. Methods: Following the standards for reporting of diagnostic accuracy studies (STARD) statement, a multicenter prospective study was conducted in 9 hospitals...

Description complète

Détails bibliographiques
Publié dans:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 62(2024), 6 vom: 02. Juni, Seite 535-541
Auteur principal: Xue, G C (Auteur)
Autres auteurs: Zhang, H L, Ding, X X, Xiong, F, Liu, Y H, Peng, H, Wang, C L, Zhao, Y, Yan, H L, Ren, M X, Ma, C Y, Lu, H M, Li, Y L, Meng, R F, Xie, L J, Chen, N, Cheng, X F, Wang, J J, Xin, X H, Wang, R F, Jiang, Q, Zhang, Y, Liang, G J, Li, Y Z, Kang, J N, Zhang, H M, Zhang, Y Y, Yuan, Y, Li, Y W, Su, Y L, Liu, J P, Duan, S J, Liu, Q S, Wei, J
Format: Article en ligne
Langue:Chinese
Publié: 2024
Accès à la collection:Zhonghua er ke za zhi = Chinese journal of pediatrics
Sujets:Journal Article Multicenter Study English Abstract Bilirubin RFM9X3LJ49
LEADER 01000caa a22002652c 4500
001 NLM372522726
003 DE-627
005 20250306053127.0
007 cr uuu---uuuuu
008 240521s2024 xx |||||o 00| ||chi c
024 7 |a 10.3760/cma.j.cn112140-20231106-00348  |2 doi 
028 5 2 |a pubmed25n1241.xml 
035 |a (DE-627)NLM372522726 
035 |a (NLM)38763875 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a chi 
100 1 |a Xue, G C  |e verfasserin  |4 aut 
245 1 0 |a Multicenter evaluation of the diagnostic efficacy of jaundice color card for neonatal hyperbilirubinemia 
264 1 |c 2024 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 06.06.2024 
500 |a Date Revised 21.08.2024 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a Objective: To evaluate the diagnostic efficacy and practicality of the Jaundice color card (JCard) as a screening tool for neonatal jaundice. Methods: Following the standards for reporting of diagnostic accuracy studies (STARD) statement, a multicenter prospective study was conducted in 9 hospitals in China from October 2019 to September 2021. A total of 845 newborns who were admitted to the hospital or outpatient department for liver function testing due to their own diseases. The inclusion criteria were a gestational age of ≥35 weeks, a birth weight of ≥2 000 g, and an age of ≤28 days. The neonate's parents used the JCard to measure jaundice at the neonate's cheek. Within 2 hours of the JCard measurement, transcutaneous bilirubin (TcB) was measured with a JH20-1B device and total serum bilirubin (TSB) was detected. The Pearson's correlation analysis, Bland-Altman plots and the receiver operating characteristic (ROC) curve were used for statistic analysis. Results: Out of the 854 newborns, 445 were male and 409 were female; 46 were born at 35-36 weeks of gestational age and 808 were born at ≥37 weeks of gestational age. Additionally, 432 cases were aged 0-3 days, 236 cases were aged 4-7 days, and 186 cases were aged 8-28 days. The TSB level was (227.4±89.6) μmol/L, with a range of 23.7-717.0 μmol/L. The JCard level was (221.4±77.0) μmol/L and the TcB level was (252.5±76.0) μmol/L. Both the JCard and TcB values showed good correlation (r=0.77 and 0.80, respectively) and agreements (96.0% (820/854) and 95.2% (813/854) of samples fell within the 95% limits of agreement, respectively) with TSB. The JCard value of 12 had a sensitivity of 0.93 and specificity of 0.75 for identifying a TSB ≥205.2 μmol/L, and a sensitivity of 1.00 and specificity of 0.35 for identifying a TSB ≥342.0 μmol/L. The TcB value of 205.2 μmol/L had a sensitivity of 0.97 and specificity of 0.60 for identifying TSB levels of 205.2 μmol/L, and a sensitivity of 1.00 and specificity of 0.26 for identifying TSB levels of 342.0 μmol/L. The areas under the ROC curve (AUC) of JCard for identifying TSB levels of 153.9, 205.2, 256.5, and 342.0 μmol/L were 0.96, 0.92, 0.83, and 0.83, respectively. The AUC of TcB were 0.94, 0.91, 0.86, and 0.87, respectively. There were both no significant differences between the AUC of JCard and TcB in identifying TSB levels of 153.9 and 205.2 μmol/L (both P>0.05). However, the AUC of JCard were both lower than those of TcB in identifying TSB levels of 256.5 and 342.0 μmol/L (both P<0.05). Conclusions: JCard can be used to classify different levels of bilirubin, but its diagnostic efficacy decreases with increasing bilirubin levels. When TSB level are ≤205.2 μmol/L, its diagnostic efficacy is equivalent to that of the JH20-1B. To prevent the misdiagnosis of severe jaundice, it is recommended that parents use a low JCard score, such as 12, to identify severe hyperbilirubinemia (TSB ≥342.0 μmol/L) 
650 4 |a Journal Article 
650 4 |a Multicenter Study 
650 4 |a English Abstract 
650 7 |a Bilirubin  |2 NLM 
650 7 |a RFM9X3LJ49  |2 NLM 
700 1 |a Zhang, H L  |e verfasserin  |4 aut 
700 1 |a Ding, X X  |e verfasserin  |4 aut 
700 1 |a Xiong, F  |e verfasserin  |4 aut 
700 1 |a Liu, Y H  |e verfasserin  |4 aut 
700 1 |a Peng, H  |e verfasserin  |4 aut 
700 1 |a Wang, C L  |e verfasserin  |4 aut 
700 1 |a Zhao, Y  |e verfasserin  |4 aut 
700 1 |a Yan, H L  |e verfasserin  |4 aut 
700 1 |a Ren, M X  |e verfasserin  |4 aut 
700 1 |a Ma, C Y  |e verfasserin  |4 aut 
700 1 |a Lu, H M  |e verfasserin  |4 aut 
700 1 |a Li, Y L  |e verfasserin  |4 aut 
700 1 |a Meng, R F  |e verfasserin  |4 aut 
700 1 |a Xie, L J  |e verfasserin  |4 aut 
700 1 |a Chen, N  |e verfasserin  |4 aut 
700 1 |a Cheng, X F  |e verfasserin  |4 aut 
700 1 |a Wang, J J  |e verfasserin  |4 aut 
700 1 |a Xin, X H  |e verfasserin  |4 aut 
700 1 |a Wang, R F  |e verfasserin  |4 aut 
700 1 |a Jiang, Q  |e verfasserin  |4 aut 
700 1 |a Zhang, Y  |e verfasserin  |4 aut 
700 1 |a Liang, G J  |e verfasserin  |4 aut 
700 1 |a Li, Y Z  |e verfasserin  |4 aut 
700 1 |a Kang, J N  |e verfasserin  |4 aut 
700 1 |a Zhang, H M  |e verfasserin  |4 aut 
700 1 |a Zhang, Y Y  |e verfasserin  |4 aut 
700 1 |a Yuan, Y  |e verfasserin  |4 aut 
700 1 |a Li, Y W  |e verfasserin  |4 aut 
700 1 |a Su, Y L  |e verfasserin  |4 aut 
700 1 |a Liu, J P  |e verfasserin  |4 aut 
700 1 |a Duan, S J  |e verfasserin  |4 aut 
700 1 |a Liu, Q S  |e verfasserin  |4 aut 
700 1 |a Wei, J  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Zhonghua er ke za zhi = Chinese journal of pediatrics  |d 1960  |g 62(2024), 6 vom: 02. Juni, Seite 535-541  |w (DE-627)NLM136249191  |x 0578-1310  |7 nnas 
773 1 8 |g volume:62  |g year:2024  |g number:6  |g day:02  |g month:06  |g pages:535-541 
856 4 0 |u http://dx.doi.org/10.3760/cma.j.cn112140-20231106-00348  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_20 
912 |a GBV_ILN_22 
912 |a GBV_ILN_24 
912 |a GBV_ILN_31 
912 |a GBV_ILN_39 
912 |a GBV_ILN_40 
912 |a GBV_ILN_50 
912 |a GBV_ILN_61 
912 |a GBV_ILN_65 
912 |a GBV_ILN_69 
912 |a GBV_ILN_70 
912 |a GBV_ILN_72 
912 |a GBV_ILN_120 
912 |a GBV_ILN_130 
912 |a GBV_ILN_227 
912 |a GBV_ILN_244 
912 |a GBV_ILN_285 
912 |a GBV_ILN_294 
912 |a GBV_ILN_350 
912 |a GBV_ILN_665 
912 |a GBV_ILN_813 
951 |a AR 
952 |d 62  |j 2024  |e 6  |b 02  |c 06  |h 535-541