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240517s2024 xx |||||o 00| ||eng c |
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|a 10.1111/nph.19814
|2 doi
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|a pubmed24n1430.xml
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|a DE-627
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|a eng
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|a Eljounaidi, Kaouthar
|e verfasserin
|4 aut
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| 245 |
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|a Variation of terpene alkaloids in Daphniphyllum macropodum across plants and tissues
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 06.06.2024
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|a Date Revised 06.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Authors. New Phytologist © 2024 New Phytologist Foundation.
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|a Daphniphyllum macropodum produces alkaloids that are structurally complex with polycyclic, stereochemically rich carbon skeletons. Understanding how these compounds are formed by the plant may enable exploration of their biological function and bioactivities. We employed multiple metabolomics techniques, including a workflow to annotate compounds in the absence of standards, to compare alkaloid content across plants and tissues. Different alkaloid structural types were found to have distinct distributions between genotypes, between tissues and within tissues. Alkaloid structural types also showed different isotope labelling enrichments that matched their biosynthetic relationships. The work suggests that mevalonate derived 30-carbon alkaloids are formed in the phloem region before their conversion to 22-carbon alkaloids which accumulate in the epidermis. This sets the stage for further investigation into the biosynthetic pathway
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|a Journal Article
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|a Daphniphyllum
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|a alkaloids
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| 650 |
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|a biosynthesis
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| 650 |
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|a metabolomics
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|a specialised metabolism
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|a Alkaloids
|2 NLM
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|a Terpenes
|2 NLM
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|a Radzikowska, Barbara A
|e verfasserin
|4 aut
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|a Whitehead, Caragh B
|e verfasserin
|4 aut
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|a Taylor, Danielle J
|e verfasserin
|4 aut
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|a Conde, Susana
|e verfasserin
|4 aut
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|a Davis, William
|e verfasserin
|4 aut
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|a Dowle, Adam A
|e verfasserin
|4 aut
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|a Langer, Swen
|e verfasserin
|4 aut
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|a James, Sally
|e verfasserin
|4 aut
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| 700 |
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|a Unsworth, William P
|e verfasserin
|4 aut
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|a Ezer, Daphne
|e verfasserin
|4 aut
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|a Larson, Tony R
|e verfasserin
|4 aut
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|a Lichman, Benjamin R
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 243(2024), 1 vom: 06. Juni, Seite 299-313
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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|g volume:243
|g year:2024
|g number:1
|g day:06
|g month:06
|g pages:299-313
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|u http://dx.doi.org/10.1111/nph.19814
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