Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes
Immune stimulating complexes (ISCOMs) are safe and effective saponin-based adjuvants formed by the self-assembly of saponin, cholesterol, and phospholipids in water to form cage-like 30-40 nm diameter particles. Inclusion of the Toll-like receptor 4 agonist monophosphoryl lipid A (MPLA) in ISCOM par...
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Bibliographische Detailangaben
| Veröffentlicht in: | Chemical engineering journal (Lausanne, Switzerland : 1996). - 1999. - 464(2023) vom: 15. Mai
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| 1. Verfasser: |
Pires, Ivan S
(VerfasserIn) |
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| Weitere Verfasser: |
Ni, Kaiyuan,
Melo, Mariane Bandeira,
Li, Na,
Ben-Akiva, Elana,
Maiorino, Laura,
Dye, Jonathan,
Rodrigues, Kristen A,
Yun, DongSoo,
Kim, Byungji,
Hosn, Ryan R,
Hammond, Paula T,
Irvine, Darrell J |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2023
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| Zugriff auf das übergeordnete Werk: | Chemical engineering journal (Lausanne, Switzerland : 1996)
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| Schlagworte: | Journal Article
SMNP
adjuvants
immune stimulating complexes
monophosphoryl lipid A
saponin
tangential flow filtration
vaccines |
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