Integration of multi-omics analysis reveals metabolic alterations of B lymphocytes in systemic lupus erythematosus

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 264(2024) vom: 10. Juni, Seite 110243
1. Verfasser: Iperi, Cristian (VerfasserIn)
Weitere Verfasser: Fernández-Ochoa, Álvaro, Pers, Jacques-Olivier, Barturen, Guillermo, Alarcón-Riquelme, Marta, PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium, Quirantes-Piné, Rosa, Borrás-Linares, Isabel, Segura-Carretero, Antonio, Cornec, Divi, Bordron, Anne, Jamin, Christophe
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article B lymphocytes MOFA Metabolomics Multi-omics Systemic lupus erythematosus
Beschreibung
Zusammenfassung:Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To link changes in the B-cell transcriptome from systemic lupus erythematosus (SLE) patients with those in their macroenvironment, including cellular and fluidic components
METHODS: Analysis was performed on 363 patients and 508 controls, encompassing transcriptomics, metabolomics, and clinical data. B-cell and whole-blood transcriptomes were analysed using DESeq and GSEA. Plasma and urine metabolomics peak changes were quantified and annotated using Ceu Mass Mediator database. Common sources of variation were identified using MOFA integration analysis
RESULTS: Cellular macroenvironment was enriched in cytokines, stress responses, lipidic synthesis/mobility pathways and nucleotide degradation. B cells shared these pathways, except nucleotide degradation diverted to nucleotide salvage pathway, and distinct glycosylation, LPA receptors and Schlafen proteins
CONCLUSIONS: B cells showed metabolic changes shared with their macroenvironment and unique changes directly or indirectly induced by IFN-α signalling. This study underscores the importance of understanding the interplay between B cells and their macroenvironment in SLE pathology
Beschreibung:Date Completed 14.06.2024
Date Revised 14.06.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110243