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240503s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110233
|2 doi
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|a pubmed24n1509.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Covino, Daniela Angela
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Absence of ATM leads to altered NK cell function in mice
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 17.05.2024
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|a Date Revised 22.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 Elsevier Inc. All rights reserved.
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|a Ataxia-telangiectasia (A-T) is a rare disorder caused by genetic defects of A-T mutated (ATM) kinase, a key regulator of stress response, and characterized by neurodegeneration, immunodeficiency, and high incidence of cancer. Here we investigated NK cells in a mouse model of A-T (Atm-/-) showing that they are strongly impaired at killing tumor cells due to a block of early signaling events. On the other hand, in Atm-/- littermates with thymic lymphoma NK cell cytotoxicity is enhanced as compared with ATM-proficient mice, possibly via tumor-produced TNF-α. Results also suggest that expansion of exhausted NKG2D+ NK cells in Atm-/- mice is driven by low-level expression of stress-inducible NKG2D ligands, whereas development of thymoma expressing the high-affinity MULT1 ligand is associated with NKG2D down-regulation on NK cells. These results expand our understanding of immunodeficiency in A-T and encourage exploring NK cell biology in A-T patients in the attempt to identify cancer predictive biomarkers and novel therapeutic targets
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|a Journal Article
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|a ATM kinase
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| 650 |
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|a Ataxia-telangiectasia
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|a Cytotoxicity
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| 650 |
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4 |
|a H60
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| 650 |
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4 |
|a MULT1
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| 650 |
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4 |
|a NKG2D
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| 650 |
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4 |
|a Natural killer cells
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| 650 |
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4 |
|a RAE-1
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| 650 |
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4 |
|a TNF-α
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| 650 |
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|a Klrk1 protein, mouse
|2 NLM
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| 650 |
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7 |
|a Atm protein, mouse
|2 NLM
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| 650 |
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7 |
|a UL16 binding protein 1, mouse
|2 NLM
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| 700 |
1 |
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|a Desimio, Maria Giovanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Giovinazzo, Alessandro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a de Oliveira, Bruna Sabino Pinho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Merolle, Matilde
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marazziti, Daniela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pellegrini, Manuela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Doria, Margherita
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 263(2024) vom: 22. Juni, Seite 110233
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:263
|g year:2024
|g day:22
|g month:06
|g pages:110233
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|u http://dx.doi.org/10.1016/j.clim.2024.110233
|3 Volltext
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