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240501s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202401222
|2 doi
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|a pubmed24n1474.xml
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|a (DE-627)NLM371793610
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|a (NLM)38690593
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Wang, Dianyu
|e verfasserin
|4 aut
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|a A Dual-Channel Ca2+ Nanomodulator Induces Intracellular Ca2+ Disorders via Endogenous Ca2+ Redistribution for Tumor Radiosensitization
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 18.07.2024
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|a Date Revised 18.07.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Tumor cells harness Ca2+ to maintain cellular homeostasis and withstand external stresses from various treatments. Here, a dual-channel Ca2+ nanomodulator (CAP-P-NO) is constructed that can induce irreversible intracellular Ca2+ disorders via the redistribution of tumor-inherent Ca2+ for disrupting cellular homeostasis and thus improving tumor radiosensitivity. Stimulated by tumor-overexpressed acid and glutathione, capsaicin and nitric oxide are successively escaped from CAP-P-NO to activate the transient receptor potential cation channel subfamily V member 1 and the ryanodine receptor for the influx of extracellular Ca2+ and the release of Ca2+ in the endoplasmic reticulum, respectively. The overwhelming level of Ca2+ in tumor cells not only impairs the function of organelles but also induces widespread changes in the gene transcriptome, including the downregulation of a set of radioresistance-associated genes. Combining CAP-P-NO treatment with radiotherapy achieves a significant suppression against both pancreatic and patient-derived hepatic tumors with negligible side effects. Together, the study provides a feasible approach for inducing tumor-specific intracellular Ca2+ overload via endogenous Ca2+ redistribution and demonstrates the great potential of Ca2+ disorder therapy in enhancing the sensitivity for tumor radiotherapy
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|a Journal Article
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|a Ca2+ nanomodulator
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|a cellular homeostasis disruption
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|a intracellular Ca2+ disorder
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|a radiosensitization
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4 |
|a self‐assembling peptide
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|a Calcium
|2 NLM
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| 650 |
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|a SY7Q814VUP
|2 NLM
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| 650 |
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|a Radiation-Sensitizing Agents
|2 NLM
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| 700 |
1 |
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|a Jia, Haixue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Hongmei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hou, Xiaoxue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Jia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jinjian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Lijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jianfeng
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 29 vom: 10. Juli, Seite e2401222
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:36
|g year:2024
|g number:29
|g day:10
|g month:07
|g pages:e2401222
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|u http://dx.doi.org/10.1002/adma.202401222
|3 Volltext
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