|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM371527279 |
| 003 |
DE-627 |
| 005 |
20250306032629.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
240426s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/acs.langmuir.4c00787
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1237.xml
|
| 035 |
|
|
|a (DE-627)NLM371527279
|
| 035 |
|
|
|a (NLM)38663878
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Hu, Jie
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Photoresponsive Azobenzene Nanocluster-Modified Liposomes
|b Mechanism Analysis Combining Experiments and Simulations
|
| 264 |
|
1 |
|c 2024
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 07.05.2024
|
| 500 |
|
|
|a Date Revised 07.05.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Stimuli-responsive behaviors and controlled release in liposomes are pivotal in nanomedicine. To this end, we present an approach using a photoresponsive azobenzene nanocluster (AzDmpNC), prepared from azobenzene compounds through melting and aggregation. When integrated with liposomes, they form photoresponsive vesicles. The morphology and association with liposomes were investigated by using transmission electron microscopy. Liposomes loaded with calcein exhibited a 9.58% increased release after UV exposure. To gain insights into the underlying processes and elucidate the mechanisms involved. The molecular dynamic simulations based on the reactive force field and all-atom force field were employed to analyze the aggregation of isomers into nanoclusters and their impacts on phospholipid membranes, respectively. The results indicate that the nanoclusters primarily aggregate through π-π and T-stacking forces. The force density inside the cis-isomer of AzDmpNC formed after photoisomerization is lower, leading to its easier dispersion, rapid diffusion, and penetration into the membrane, disrupting the densification
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Azo Compounds
|2 NLM
|
| 650 |
|
7 |
|a azobenzene
|2 NLM
|
| 650 |
|
7 |
|a F0U1H6UG5C
|2 NLM
|
| 650 |
|
7 |
|a Liposomes
|2 NLM
|
| 650 |
|
7 |
|a Fluoresceins
|2 NLM
|
| 650 |
|
7 |
|a fluorexon
|2 NLM
|
| 650 |
|
7 |
|a V0YM2B16TS
|2 NLM
|
| 700 |
1 |
|
|a Pang, Jingtao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Lijuan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Yilin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gan, Na
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Pan, Qingqing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wu, Di
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 40(2024), 18 vom: 07. Mai, Seite 9761-9774
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
|
| 773 |
1 |
8 |
|g volume:40
|g year:2024
|g number:18
|g day:07
|g month:05
|g pages:9761-9774
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/acs.langmuir.4c00787
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 40
|j 2024
|e 18
|b 07
|c 05
|h 9761-9774
|