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|a 10.1093/jxb/erae177
|2 doi
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|a eng
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|a Dard, Avilien
|e verfasserin
|4 aut
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|a Redox regulation of gene expression
|b proteomics reveals multiple previously undescribed redox-sensitive cysteines in transcription complexes and chromatin modifiers
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 12.08.2024
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|a Date Revised 12.08.2024
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For commercial re-use, please contact reprintsoup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
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|a Redox signalling is crucial for regulating plant development and adaptation to environmental changes. Proteins with redox-sensitive cysteines can sense oxidative stress and modulate their functions. Recent proteomics efforts have comprehensively mapped the proteins targeted by oxidative modifications. The nucleus, the epicentre of transcriptional reprogramming, contains a large number of proteins that control gene expression. Specific redox-sensitive transcription factors have long been recognized as key players in decoding redox signals in the nucleus and thus in regulating transcriptional responses. Consequently, the redox regulation of the nuclear transcription machinery and its cofactors has received less attention. In this review, we screened proteomic datasets for redox-sensitive cysteines on proteins of the core transcription complexes and chromatin modifiers in Arabidopsis thaliana. Our analysis indicates that redox regulation affects every step of gene transcription, from initiation to elongation and termination. We report previously undescribed redox-sensitive subunits in transcription complexes and discuss the emerging challenges in unravelling the landscape of redox-regulated processes involved in nuclear gene transcription
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|a Journal Article
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|a Review
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|a Acetylation
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|a gene expression
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|a histones
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|a mediator complex
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|a reactive oxygen/nitrogen species
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|a redox-sensitive cysteines
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|a transcription complex
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|a Chromatin
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|a Cysteine
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|a K848JZ4886
|2 NLM
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|a Arabidopsis Proteins
|2 NLM
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|a Van Breusegem, Frank
|e verfasserin
|4 aut
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|a Mhamdi, Amna
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 75(2024), 15 vom: 12. Aug., Seite 4476-4493
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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|g volume:75
|g year:2024
|g number:15
|g day:12
|g month:08
|g pages:4476-4493
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|u http://dx.doi.org/10.1093/jxb/erae177
|3 Volltext
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