Defining remission in childhood-onset lupus PReS-endorsed consensus definitions by an international task force

Defining remission in childhood-onset lupus : PReS-endorsed consensus definitions by an international task force

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 263(2024) vom: 15. Juni, Seite 110214
1. Verfasser: Smith, E M D (VerfasserIn)
Weitere Verfasser: Aggarwal, A (BerichterstatterIn), Ainsworth, J (BerichterstatterIn), Al-Abadi, E (BerichterstatterIn), Avcin, T (BerichterstatterIn), Bortey, L, Burnham, J, Ciurtin, C, Hedrich, C M, Kamphuis, S, Lambert, L, Levy, D M, Lewandowski, L, Maxwell, N, Morand, E, Özen, S, Pain, C E, Ravelli, A, Saad Magalhaes, C, Pilkington, C, Schonenberg-Meinema, D, Scott, C, Tullus, K, Beresford, M W, International cSLE T2T Task Force, Goilav, B, Goss, N, Oni, L, Marks, S D
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Childhood-onset SLE Remission T2T Treat-to-target cSLE
Beschreibung
Zusammenfassung:Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice
METHODS: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria
RESULTS: The Task Force proposed two definitions of remission: 'cSLE clinical remission on steroids (cCR)' and 'cSLE clinical remission off steroids (cCR-0)'. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0-3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero
CONCLUSIONS: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research
Beschreibung:Date Completed 17.05.2024
Date Revised 17.05.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110214