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240411s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202403355
|2 doi
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|a pubmed24n1453.xml
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|a (DE-627)NLM370879767
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|a (NLM)38598646
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Liu, Xingang
|e verfasserin
|4 aut
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1 |
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|a Living Artificial Skin
|b Photosensitizer and Cell Sandwiched Bacterial Cellulose for Chronic Wound Healing
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 26.06.2024
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|a Date Revised 26.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Chronic wounds pose a significant global public health challenge due to their suboptimal treatment efficacy caused by bacterial infections and microcirculatory disturbances. Inspired by the biofunctionality of natural skin, an artificial skin (HVBC@TBG) is bioengineered with bacterial cellulose (BC) sandwiched between photosensitizers (PS) and functionalized living cells. Glucose-modified PS (TBG) and vascular endothelial growth factor (VEGF)-functionalized living cells (HV) are successively modified on each side of BC through biological metabolism and bio-orthogonal reaction. As the outermost layer, the TBG layer can generate reactive oxygen species (ROS) upon light illumination to efficiently combat bacterial infections. The HV layer is the inner layer near the diabetic wound, which servs as a living factory to continuously secrete VEGF to accelerate wound repair by promoting fibroblast proliferation and angiogenesis. The sandwiched structural artificial skin HV@BC@TBG is nontoxic, biocompatible, and demonstrated its ability to significantly accelerate the healing process of infected diabetic wounds, rendering it a promising next-generation medical therapy for chronic wound management
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|a Journal Article
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|a aggregation‐induced emission
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|a artificial skin
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|a chronic wound
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|a living materials
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|a photodynamic therapy
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|a Cellulose
|2 NLM
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|a 9004-34-6
|2 NLM
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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|a Vascular Endothelial Growth Factor A
|2 NLM
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| 650 |
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|a Reactive Oxygen Species
|2 NLM
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| 650 |
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|a Glucose
|2 NLM
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| 650 |
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|a IY9XDZ35W2
|2 NLM
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| 700 |
1 |
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|a Wang, Meng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhuang, Jiahao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Dandan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Bin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 26 vom: 10. Juni, Seite e2403355
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:36
|g year:2024
|g number:26
|g day:10
|g month:06
|g pages:e2403355
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|u http://dx.doi.org/10.1002/adma.202403355
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