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240331s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c03739
|2 doi
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|a pubmed24n1501.xml
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|a eng
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|a Aligholizadeh, Dariush
|e verfasserin
|4 aut
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|a Detection with NO Modification
|b (N═O)-Au Interactions for Instantaneous Label-Free Detection of N-Nitrosodiphenylamine
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 10.04.2024
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|a Date Revised 14.08.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Increasing concerns have been raised about dangerous, yet nearly undetectable levels of nitrosamines in foods, medications, and drinking water. Their ubiquitous presence and carcinogenicity necessitates a method of sensitive and selective detection of these potent toxins. While the detection of two major nitrosamines─N-nitrosodimethylamine and N-nitrosodiethylamine─has seen success, low detection limits are scarcer for the other members of this class. One member, N-nitrosodiphenylamine (NDPhA), has had little progress not only in its detection in low quantities but also in its detection at all. NDPhA has unique difficulty in its identification due to its aromaticity, making it far more problematic to distinguish in the common GC-MS or LC-MS/MS methods used for nitrosamine sensing. Despite this detection barrier, it has been listed among the top 6 carcinogenic nitrosamines by the Food and Drug Administration as of 2023. Due to its evasive nature, a unique methodology must be applied to facilitate its sensitive identification. Herein, we describe the use of surface-enhanced Raman spectroscopy for the first account of liquid-phase detection of NDPhA using cysteamine-functionalized gold nanostars and a portable Raman spectrometer. Our methodology requires no chemical modification to the nitrosated structure as well as the usage of two well-understood biocompatible materials: cysteamine and gold nanoparticles
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a N-nitrosodiphenylamine
|2 NLM
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|a AP2V89J1DA
|2 NLM
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|a Cysteamine
|2 NLM
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|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a Nitrosamines
|2 NLM
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|a Johnson, Mansoor
|e verfasserin
|4 aut
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|a Hondrogiannis, Ellen
|e verfasserin
|4 aut
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|a Devadas, Mary Sajini
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 40(2024), 14 vom: 09. Apr., Seite 7405-7411
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:40
|g year:2024
|g number:14
|g day:09
|g month:04
|g pages:7405-7411
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|u http://dx.doi.org/10.1021/acs.langmuir.3c03739
|3 Volltext
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