Widefield, Swept-Source Optical Coherence Tomography Angiography Metrics as Predictors of Anti-VEGF Treatment in Retinal Vein Occlusions

Widefield, Swept-Source Optical Coherence Tomography Angiography Metrics as Predictors of Anti-VEGF Treatment in Retinal Vein Occlusions

BACKGROUND AND OBJECTIVE: Our objective was to assess baseline widefield swept-source optical coherence tomography angiography (WF SSOCTA) microvascular metrics as predictors for the number of anti-vascular endothelial growth factor (VEGF) injections and visual acuity (VA) at 12-months follow-up in...

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Détails bibliographiques
Publié dans:Ophthalmic surgery, lasers & imaging retina. - 2013. - 55(2024), 7 vom: 01. Juli, Seite 374-382
Auteur principal: Finn, Matthew J (Auteur)
Autres auteurs: Baldwin, Grace, Lains, Ines, Garg, Itika, Wescott, Hannah, Vingopoulos, Filippos, Zeng, Rebecca, Choi, Hanna, Tracy, Jack, Razavi, Peyman, Sayeh, Diane, Patel, Nimesh A, Wu, David M, Vavvas, Demetrios G, Miller, John B
Format: Article en ligne
Langue:English
Publié: 2024
Accès à la collection:Ophthalmic surgery, lasers & imaging retina
Sujets:Journal Article Angiogenesis Inhibitors Vascular Endothelial Growth Factor A Ranibizumab ZL1R02VT79
Description
Résumé:BACKGROUND AND OBJECTIVE: Our objective was to assess baseline widefield swept-source optical coherence tomography angiography (WF SSOCTA) microvascular metrics as predictors for the number of anti-vascular endothelial growth factor (VEGF) injections and visual acuity (VA) at 12-months follow-up in patients with retinal vein occlusion (RVO)
PATIENTS AND METHODS: This was a prospective study including 49 RVO eyes from 49 patients who had not received an anti-VEGF injection for at least 3 months prior to imaging. Microvascular metrics from 6×6-mm and 12×12-mm angiograms were assessed using linear regression models, adjusting for age
RESULTS: Reductions in the vessel density (VD) and vessel skeletonized density (VSD) vascular metrics were associated both with a higher number of anti-VEGF injections at all follow-up time points and reduced VA 12 months after imaging in all RVO eyes
CONCLUSIONS: WF SS-OCTA VD and VSD micro-vascular metrics at baseline can prognosticate VA and number of anti-VEGF injections required at 3, 6, and 12 months in RVO eyes. [Ophthalmic Surg Lasers Imaging Retina 2024;55:374-382.]
Description:Date Completed 16.07.2024
Date Revised 14.08.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:2325-8179
DOI:10.3928/23258160-20240208-02