Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus

Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Détails bibliographiques
Publié dans:Clinical immunology (Orlando, Fla.). - 1999. - 262(2024) vom: 15. Mai, Seite 110194
Auteur principal: Renaudineau, Yves (Auteur)
Autres auteurs: Charras, Amandine, Natoli, Valentina, Fusaro, Mathieu, Smith, Eve M D, Beresford, Michael W, Hedrich, Christian M, UK jSLE Cohort Study
Format: Article en ligne
Langue:English
Publié: 2024
Accès à la collection:Clinical immunology (Orlando, Fla.)
Sujets:Journal Article Review Epistasis Interferon Juvenile-onset systemic lupus erythematosus QTL SLEDAI-2 K jSLE Interferon-Induced Helicase, IFIH1 EC 3.6.4.13 plus... Interferon Type I Toll-Like Receptor 7 Interferon Regulatory Factors MicroRNAs
Description
Résumé:Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and damage, which likely relates to increased genetic burden. To identify T1IFN-associated gene polymorphisms (TLR7, IRAK1, miR-3142/miR-146a, IRF5, IRF7, IFIH1, IRF8, TYK2, STAT4), identify long-range linkage disequilibrium and gene:gene interrelations, 319 jSLE patients were genotyped using panel sequencing. Coupling phenotypic quantitative trait loci (QTL) analysis identified 10 jSLE QTL that associated with young age at onset (<12 years; IRAK1 [rs1059702], TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760, rs3747517], STAT4 [rs3021866], TYK2 [rs280501], IRF8 [rs1568391, rs6638]), global disease activity (SLEDAI-2 K >10; IFIH1 [rs1990760], STAT4 [rs3021866], IRF8 [rs903202, rs1568391, rs6638]), and mucocutaneous involvement (TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760]). This study suggests T1IFN-associated polymorphisms and gene:gene interrelations in jSLE. Genotyping of jSLE patients may allow for individualized treatment and care
Description:Date Completed 15.04.2024
Date Revised 15.04.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.110194