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240320s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c03692
|2 doi
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|a eng
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| 100 |
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|a Wang, Hongdong
|e verfasserin
|4 aut
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| 245 |
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|a Superlubricity Achieved by a Transparent Poly(vinylpyrrolidone) Composite Hydrogel with Glycerol Ethoxylate in Ocular Conditions
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|c 2024
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|a Text
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|a ƒaComputermedien
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|a Date Revised 02.04.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Efficient and stable ocular lubrication is pivotal in safeguarding eye tissues from wear, especially under repetitive strain due to frequent blinking. Hydrogels have been reported to possess adjustable mechanical properties, biocompatibility, durability, and elevated water content and extensive utilization in medical fields. In this work, a kind of visible photo-cross-linking poly(vinylpyrrolidone) (PVP) hydrogel was designed and synthesized using 1-vinyl-2-pyrrolidone (NVP) and poly(ethylene glycol) diacrylate (PEGDA). To optimize the structure and improve the lubrication performance of hydrogels, we prepared and investigated glycerol ethoxylate (GE)-introduced composite hydrogels (GE/PVP). The results show that the addition of 3 wt % GE helped the hydrogel to form a uniform and dense porous matrix and reduce the frictional coefficient (COF) by over 50%, achieving superlubricity (COF ≈ 0.005). However, with the excessive increase of GE (6 wt %), the structure of the hydrogel is destroyed, inducing pore walls to thin and expand. After that, a lubrication mechanism of the GE/PVP composite hydrogel was proposed, in which the addition of GE reduced the surface tension of the hydrogel, enhanced the hydration ability of the hydrogel, and thus decreased the friction between sliding surfaces. Besides, the cytotoxicity tests show that the composite hydrogels possess good biocompatibility. Overall, the as-synthesized hydrogels hold great potential as lubricating medium for use in ocular applications
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|a Journal Article
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1 |
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|a Zhao, Haiyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Xingyang
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Xiacong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Junyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Yuhong
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Jianhua
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 40(2024), 13 vom: 02. Apr., Seite 6816-6823
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|g year:2024
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|g day:02
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|g pages:6816-6823
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|u http://dx.doi.org/10.1021/acs.langmuir.3c03692
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