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20240415233432.0 |
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240316s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.110172
|2 doi
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|a pubmed24n1376.xml
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|a (DE-627)NLM369800206
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|a (NLM)38490344
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|a (PII)S1521-6616(24)00063-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Bergkamp, Sandy C
|e verfasserin
|4 aut
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| 245 |
1 |
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|a First validation of the childhood lupus low disease activity state (cLLDAS) definition in a real-life longitudinal cSLE cohort
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.04.2024
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|a Date Revised 15.04.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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|a OBJECTIVES: To validate the childhood lupus low disease activity state (cLLDAS) definition in cSLE by describing differences in time to reach first adult LLDAS (aLLDAS) versus cLLDAS. Secondly, to analyse positive and negative predictors for maintaining cLLDAS for at least 50% of follow-up time (cLLDAS-50) and for the occurrence of damage
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|a METHODS: Prospective longitudinal data from a cSLE cohort were analysed. Used definitions were: aLLDAS according to Franklyn, cLLDAS by cSLE treat-to-target (T2T) Task Force, disease activity score by SLEDAI -2 K and damage by SLICC damage index
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|a RESULTS: Fifty cSLE patients were studied, with a median follow-up of 3.1 years. Each patient reached aLLDAS and cLLDAS at least once. Mean time to reach first aLLDAS/cLLDAS was 8.2/9.0 months, respectively. For 22/42 patients the mean steroid-dose related delay to reach first cLLDAS was 6.2 months. 58% of patients were able to maintain cLLDAS-50. Time to first cLLDAS (OR 0.8, p = 0.013) and higher number of flares (OR 0.374, p = 0.03) were negative predictors to maintain cLLDAS-50. Damage occurred in 34% of patients (23.5% steroid-related), in 64.7% within one year after diagnosis. African/Afro-Caribbean ethnicity, neuropsychiatric involvement and ever use of a biologic were significant predictors for damage
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|a CONCLUSION: Time to reach cLLDAS in cSLE differs from time to (a)LLDAS, which validates the new cLLDAS definition. Attaining cLLDAS-50 was difficult in real-life. This cohort shows the high risk for early damage in cSLE. T2T with earlier focus on steroid-tapering and starting steroid-sparing drugs seems important to prevent (steroid-related) damage in cSLE
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|a Journal Article
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|a Childhood-onset SLE (cSLE)
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|a Childhood-onset lupus low disease activity state (cLLDAS)
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| 650 |
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|a Damage
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| 650 |
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|a Treat-to-target (T2T)
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| 650 |
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|a Steroids
|2 NLM
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| 700 |
1 |
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|a Kanagasabapathy, Thipa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gruppen, Mariken P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kuijpers, Taco W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rashid, Amara Nassar-Sheikh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van den Berg, J Merlijn
|e verfasserin
|4 aut
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| 700 |
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|a Schonenberg-Meinema, Dieneke
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 262(2024) vom: 15. Apr., Seite 110172
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:262
|g year:2024
|g day:15
|g month:04
|g pages:110172
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2024.110172
|3 Volltext
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