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|a Chevallier, Lucie
|e verfasserin
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|a Clinical, pathologic, and molecular characterization of a non-metastatic multicentric cutaneous mast cell tumor in a cow
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|c 2024
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|a Text
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|a Date Completed 14.03.2024
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|a Date Revised 14.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.
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|a Cutaneous mast cell tumors are rarely reported in cattle. Although mutations in the c-KIT gene have been shown to play a central role in the oncogenesis of canine mast cell tumors, few data are available in cattle. This report describes the clinical, histologic, immunohistochemical, and genetic features of a multicentric cutaneous mast cell tumor in an adult cow. An 11-year-old Prim'Holstein cow was presented for a 5-month history of multiple skin nodules. Cytologic and histologic analyses of the nodules led to a diagnosis of mast cell tumors. Immunohistochemical analysis for KIT expression showed a moderate to strong signal in neoplastic mast cells with a cytoplasmic and membranous pattern. Sequencing of the c-KIT gene coding sequence revealed no mutation. Despite partial response after corticosteroid treatment, euthanasia was elected. No metastases to the lymph nodes, spleen, and liver were identified at post-mortem and histologic examinations
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|a Case Reports
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|a c-KIT oncogene
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|a cattle
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|a genetics
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| 650 |
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4 |
|a histology
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| 650 |
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|a skin tumor
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| 650 |
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|a Proto-Oncogene Proteins c-kit
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|a Briand, Amaury
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|a Defer, Wilfried
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|a Millemann, Yves
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|a Béguin, Jérémy
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