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240229s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202401111
|2 doi
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|a pubmed25n1229.xml
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|a (NLM)38412487
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|a DE-627
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|a eng
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|a Wang, Yan
|e verfasserin
|4 aut
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|a Synergizing Pyroelectric Catalysis and Enzyme Catalysis
|b Establishing a Reciprocal and Synergistic Model to Enhance Anti-Tumor Activity
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 13.06.2024
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|a Date Revised 13.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Nanozyme activity is greatly weakened by the microenvironment and multidrug resistance of tumor cells. Hence, a bi-catalytic nanoplatform, which promotes the anti-tumor activity through "charging empowerment" and "mutual complementation" processes involved in enzymatic and pyroelectric catalysis, by loading ultra-small nanoparticles (USNPs) of pyroelectric ZnSnO3 onto MXene nanozyme (V2CTx nanosheets), is developed. Here, the V2CTx nanosheets exhibit enhanced peroxidase activity by reacting V3+ with H2O2 to generate toxic ·OH, accelerated by the near-infrared (NIR) light mediated heat effect. The resulting V4+ is then converted to V3+ by oxidizing endogenous glutathione (GSH), realizing an enzyme-catalyzed cycle. However, the cycle will lose its persistence once GSH is insufficient; nevertheless, the pyroelectric charges generated by ZnSnO3 USNPs continuously support the V4+/V3+ conversion and ensure nanoenzyme durability. Moreover, the hyperthermia arising from the V2CTx nanosheets by NIR irradiation results in an ideal local temperature gradient for the ZnSnO3 USNPs, giving rise to an excellent pyroelectric catalytic effect by promoting band bending. Furthermore, polarized charges increase the tumor cell membrane permeability and facilitate nanodrug accumulation, thereby resolving the multidrug resistance issue. Thus, the combination of pyroelectric and enzyme catalysis together with the photothermal effect solves the dilemma of nanozymes and improves the antitumor efficiency
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|a Journal Article
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|a MXene
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|a ZnSnO3
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|a anti‐tumor
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|a nanozymes
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|a pyroelectric catalysis
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|a Antineoplastic Agents
|2 NLM
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|a Glutathione
|2 NLM
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|a GAN16C9B8O
|2 NLM
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|a Hydrogen Peroxide
|2 NLM
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|a BBX060AN9V
|2 NLM
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| 700 |
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|a Zhang, Rui
|e verfasserin
|4 aut
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| 700 |
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|a Zang, Pengyu
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Ruoxi
|e verfasserin
|4 aut
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| 700 |
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|a Wu, Linzhi
|e verfasserin
|4 aut
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| 700 |
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|a Zhu, Yanlin
|e verfasserin
|4 aut
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|a Yang, Dan
|e verfasserin
|4 aut
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|a Gai, Shili
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Piaoping
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 24 vom: 01. Juni, Seite e2401111
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:36
|g year:2024
|g number:24
|g day:01
|g month:06
|g pages:e2401111
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|u http://dx.doi.org/10.1002/adma.202401111
|3 Volltext
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