Synergistic Interaction between Metal Single-Atoms and Defective WO3- x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 23 vom: 15. Juni, Seite e2311002
1. Verfasser:	Zhou, Zhan (VerfasserIn)
Weitere Verfasser:	Wang, Tao, Hu, Tingting, Xu, Hao, Cui, Lin, Xue, Baoli, Zhao, Xinshuo, Pan, Xiangrong, Yu, Shilong, Li, Hai, Qin, Yong, Zhang, Jiankang, Ma, Lufang, Liang, Ruizheng, Tan, Chaoliang
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article 2D WO3−x nanosheets Cu single‐atoms oxygen vacancies sonodynamic therapy synergistic interaction Tungsten V9306CXO6G tungsten oxide 940E10M08M mehr... Oxides Reactive Oxygen Species Antineoplastic Agents Copper 789U1901C5

Beschreibung
Zusammenfassung:	© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH. Although metal single-atom (SA)-based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of metal SAs on oxygen vacancy (OV)-rich WO3- x nanosheets to generate a synergistic effect for efficient SDT is reported. Crystalline WO3 and OV-rich WO3- x nanosheets are first prepared by simple calcination of the WO3·H2O nanosheets under an air and N2 atmosphere, respectively. Pt, Cu, Fe, Co, and Ni metal SAs are then deposited on WO3- x nanosheets to obtain metal SA-decorated WO3- x nanocomposites (M-WO3- x). Importantly, the Cu-WO3- x sonosensitizer exhibits a much higher activity for ultrasound (US)-induced production of reactive oxygen species than that of the WO3- x and Cu SA-decorated WO3, which is also higher than other M-WO3- x nanosheets. Both the experimental and theoretical results suggest that the excellent SDT performance of the Cu-WO3- x nanosheets should be attributed to the synergistic effect between Cu SAs and WO3- x OVs. Therefore, after polyethylene glycol modification, the Cu-WO3- x can quickly kill cancer cells in vitro and effectively eradicate tumors in vivo under US irradiation. Transcriptome sequencing analysis and further molecular validation suggest that the Cu-WO3- x-mediated SDT-activated apoptosis and TNF signaling pathways are potential drivers of tumor apoptosis induction
Beschreibung:	Date Completed 07.06.2024 Date Revised 07.06.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202311002