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240229s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202307845
|2 doi
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|a pubmed24n1439.xml
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|a (DE-627)NLM368986926
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|a (NLM)38408735
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|a DE-627
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|e rakwb
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|a eng
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|a Tang, Fuxin
|e verfasserin
|4 aut
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|a Double-Layer Asymmetric Porous Mesh with Dynamic Mechanical Support Properties Enables Efficient Single-Stage Repair of Contaminated Abdominal Wall Defect
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 13.06.2024
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|a Date Revised 13.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Contamination tolerance and long-term mechanical support are the two critical properties of meshes for contaminated abdominal wall defect repair. However, biological meshes with excellent pollution tolerance fail to provide bio-adaptive long-term mechanical support due to their rapid degradation. Here, a novel double-layer asymmetric porous mesh (SIS/PVA-EXO) is designed by simple and efficient in situ freeze-thaw of sticky polyvinyl alcohol (PVA) solution on the loosely porous surface of small intestinal submucosal decellularized matrix (SIS), which can successfully repair the contaminated abdominal wall defect with bio-adaptive dynamic mechanical support through only single-stage surgery. The exosome-loaded degradable loosely porous SIS layer accelerates the tissue healing; meanwhile, the exosome-loaded densely porous PVA layer can maintain long-term mechanical support without any abdominal adhesion. In addition, the tensile strength and strain at break of SIS/PVA-EXO mesh change gradually from 0.37 MPa and 210% to 0.10 MPa and 385% with the degradation of SIS layer. This unique performance can dynamically adapt to the variable mechanical demands during different periods of contaminated abdominal wall reconstruction. As a result, this SIS/PVA-EXO mesh shows an attractive prospect in the treatment of contaminated abdominal wall defect without recurrence by integrating local immune regulation, tissue remodeling, and dynamic mechanical supporting
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|a Journal Article
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|a contaminated abdominal wall defect
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|a dynamic mechanical support
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|a local immune regulation
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|a porous mesh
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|a tissue remodeling
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|a Polyvinyl Alcohol
|2 NLM
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|a 9002-89-5
|2 NLM
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| 650 |
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|a Biocompatible Materials
|2 NLM
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1 |
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|a Miao, Dongtian
|e verfasserin
|4 aut
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1 |
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|a Huang, Rongkang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Bingna
|e verfasserin
|4 aut
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| 700 |
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|a Yu, Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Pengwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Peng, Binying
|e verfasserin
|4 aut
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| 700 |
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|a Li, Yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Dingcai
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 24 vom: 11. Juni, Seite e2307845
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:36
|g year:2024
|g number:24
|g day:11
|g month:06
|g pages:e2307845
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202307845
|3 Volltext
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