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240229s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202311291
|2 doi
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|a pubmed24n1432.xml
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|a eng
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|a Li, Xinyue
|e verfasserin
|4 aut
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|a Octadecyl Gallate and Lipid-Modified MnSe2 Nanoparticles Enhance Radiosensitivity in Esophageal Squamous Cell Carcinoma and Promote Radioprotection in Normal Tissues
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 07.06.2024
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|a Date Revised 07.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Radiotherapy, a widely used therapeutic strategy for esophageal squamous cell carcinoma (ESCC), is always limited by radioresistance of tumor tissues and side-effects on normal tissues. Herein, a signature based on four core genes of cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is developed to predict prognosis and assess immune cell infiltration, indicating that the cGAS-STING pathway and radiotherapy efficacy are closely intertwined in ESCC. A novel lipid-modified manganese diselenide nanoparticle (MnSe2-lipid) with extraordinarily uniform sphere morphology and tumor microenvironment (TME) responsiveness is developed to simultaneously overcome radioresistance and reduce side-effects of radiation. The uniform MnSe2 encapsulated lipid effectively achieves tumor accumulation. Octadecyl gallate on surface of MnSe2 forming pH-responsive metal-phenolic covalent realizes rapid degradation in TME. The released Mn2+ promotes radiosensitivity by generating reactive oxygen species induced by Fenton-like reaction and activating cGAS-STING pathway. Spontaneously, selenium strengthens immune response by promoting secretion of cytokines and increasing white blood cells, and performs antioxidant activity to reduce side-effects of radiotherapy. Overall, this multifunctional remedy which is responsive to TME is capable of providing radiosensitivity by cGAS-STING pathway-mediated immunostimulation and chemodynamic therapy, and radioprotection of normal tissues, is highlighted here to optimize ESCC treatment
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|a Journal Article
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|a MnSe2‐lipid
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|a cyclic GMP‐AMP synthase‐stimulator of interferon genes
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|a esophageal squamous cell carcinoma
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|a radioprotection
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|a radiosensitivity
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|a Gallic Acid
|2 NLM
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|a 632XD903SP
|2 NLM
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|a Lipids
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|a Selenium
|2 NLM
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|a H6241UJ22B
|2 NLM
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|a Radiation-Protective Agents
|2 NLM
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|a Manganese
|2 NLM
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|a 42Z2K6ZL8P
|2 NLM
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|a Radiation-Sensitizing Agents
|2 NLM
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| 700 |
1 |
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|a Liu, He
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Wenyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Xuantong
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Longwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Zhihao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Aiping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Chunying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Zhihua
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, YuLiang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 23 vom: 01. Juni, Seite e2311291
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|g volume:36
|g year:2024
|g number:23
|g day:01
|g month:06
|g pages:e2311291
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|u http://dx.doi.org/10.1002/adma.202311291
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