Peptide-Driven Proton Sponge Nano-Assembly for Imaging and Triggering Lysosome-Regulated Immunogenic Cancer Cell Death

Peptide-Driven Proton Sponge Nano-Assembly for Imaging and Triggering Lysosome-Regulated Immunogenic Cancer Cell Death

© 2024 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 19 vom: 01. Mai, Seite e2307679
1. Verfasser: He, Tengyu (VerfasserIn)
Weitere Verfasser: Wen, Jing, Wang, Wenjian, Hu, Zeliang, Ling, Chuxuan, Zhao, Zhongchao, Cheng, Yong, Chang, Yu-Ci, Xu, Ming, Jin, Zhicheng, Amer, Lubna, Sasi, Lekshmi, Fu, Lei, Steinmetz, Nicole F, Rana, Tariq M, Wu, Peng, Jokerst, Jesse V
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article immunogenic cell death immunotherapies necroptosis peptides pyroptosis regulated necrosis self‐assembly Peptides Polyethyleneimine mehr... 9002-98-6 Protons
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520 |a Triggering lysosome-regulated immunogenic cell death (ICD, e.g., pyroptosis and necroptosis) with nanomedicines is an emerging approach for turning an "immune-cold" tumor "hot"-a key challenge faced by cancer immunotherapies. Proton sponge such as high-molecular-weight branched polyethylenimine (PEI) is excellent at rupturing lysosomes, but its therapeutic application is hindered by uncontrollable toxicity due to fixed charge density and poor understanding of resulted cell death mechanism. Here, a series of proton sponge nano-assemblies (PSNAs) with self-assembly controllable surface charge density and cell cytotoxicity are created. Such PSNAs are constructed via low-molecular-weight branched PEI covalently bound to self-assembling peptides carrying tetraphenylethene pyridinium (PyTPE, an aggregation-induced emission-based luminogen). Assembly of PEI assisted by the self-assembling peptide-PyTPE leads to enhanced surface positive charges and cell cytotoxicity of PSNA. The self-assembly tendency of PSNAs is further optimized by tuning hydrophilic and hydrophobic components within the peptide, thus resulting in the PSNA with the highest fluorescence, positive surface charge density, cell uptake, and cancer cell cytotoxicity. Systematic cell death mechanistic studies reveal that the lysosome rupturing-regulated pyroptosis and necroptosis are at least two causes of cell death. Tumor cells undergoing PSNA-triggered ICD activate immune cells, suggesting the great potential of PSNAs to trigger anticancer immunity 
650 4 |a Journal Article 
650 4 |a immunogenic cell death 
650 4 |a immunotherapies 
650 4 |a necroptosis 
650 4 |a peptides 
650 4 |a pyroptosis 
650 4 |a regulated necrosis 
650 4 |a self‐assembly 
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700 1 |a Wen, Jing  |e verfasserin  |4 aut 
700 1 |a Wang, Wenjian  |e verfasserin  |4 aut 
700 1 |a Hu, Zeliang  |e verfasserin  |4 aut 
700 1 |a Ling, Chuxuan  |e verfasserin  |4 aut 
700 1 |a Zhao, Zhongchao  |e verfasserin  |4 aut 
700 1 |a Cheng, Yong  |e verfasserin  |4 aut 
700 1 |a Chang, Yu-Ci  |e verfasserin  |4 aut 
700 1 |a Xu, Ming  |e verfasserin  |4 aut 
700 1 |a Jin, Zhicheng  |e verfasserin  |4 aut 
700 1 |a Amer, Lubna  |e verfasserin  |4 aut 
700 1 |a Sasi, Lekshmi  |e verfasserin  |4 aut 
700 1 |a Fu, Lei  |e verfasserin  |4 aut 
700 1 |a Steinmetz, Nicole F  |e verfasserin  |4 aut 
700 1 |a Rana, Tariq M  |e verfasserin  |4 aut 
700 1 |a Wu, Peng  |e verfasserin  |4 aut 
700 1 |a Jokerst, Jesse V  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 36(2024), 19 vom: 01. Mai, Seite e2307679  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:36  |g year:2024  |g number:19  |g day:01  |g month:05  |g pages:e2307679 
856 4 0 |u http://dx.doi.org/10.1002/adma.202307679  |3 Volltext 
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