Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome

Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome

Copyright © 2023. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 261(2024) vom: 14. Apr., Seite 109926
1. Verfasser: Sloan, Elizabeth E (VerfasserIn)
Weitere Verfasser: Kmetova, Katarina, NaveenKumar, Somanathapura K, Kluge, Lyndsay, Chong, Emily, Hoy, Claire K, Yalavarthi, Srilakshmi, Sarosh, Cyrus, Baisch, Jeanine, Walters, Lynnette, Nassi, Lorien, Fuller, Julie, Turnier, Jessica L, Pascual, Virginia, Wright, Tracey B, Madison, Jacqueline A, Knight, Jason S, Zia, Ayesha, Zuo, Yu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Antiphospholipid syndrome Calprotectin Non-criteria antiphospholipid antibodies Pediatric Thrombocytopenia Antibodies, Antiphospholipid Biomarkers beta 2-Glycoprotein I mehr... Immunoglobulin G Immunoglobulin M Prothrombin 9001-26-7 Leukocyte L1 Antigen Complex
Beschreibung
Zusammenfassung:Copyright © 2023. Published by Elsevier Inc.
Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0.008), anti-phosphatidylserine/prothrombin (aPS/PT) IgG (p < 0.001), and aPS/PT IgM (p < 0.001) were significantly associated with venous thrombosis. Positive anti-D1 IgG (p < 0.001), aPS/PT IgG (p < 0.001), and aPS/PT IgM (p = 0.001) were also associated with non-thrombotic manifestations of APS, such as thrombocytopenia. Increased levels of calprotectin were detected in children with APS. Calprotectin correlated positively with absolute neutrophil count (r = 0.63, p = 0.008) and negatively with platelet count (r = -0.59, p = 0.015). Mechanistically, plasma from pediatric APS patients with high calprotectin levels impaired platelet viability in a dose-dependent manner
Beschreibung:Date Completed 18.03.2024
Date Revised 02.04.2025
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2024.109926