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240208s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c02771
|2 doi
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|a eng
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|a De, Kathakali
|e verfasserin
|4 aut
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|a Cleavable Amphiphilic Biocides with Ester-Bearing Moieties
|b Aggregation Properties and Antibacterial Activity
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Revised 07.02.2024
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|a published: Print-Electronic
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|a Citation Status Publisher
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|a The rise of multidrug-resistant bacterial infections and the dwindling supply of newly approved antibiotics have emerged as a grave threat to public health. Toward the ever-growing necessity of the development of novel antimicrobial agents, herein, we synthesized a series of cationic amphiphilic biocides featuring two cationic headgroups separated by different hydrophobic spacers, accompanied by the inclusion of two lipophilic tails through cleavable ester functionality. The detailed aggregation properties offered by these biocides were investigated by small-angle neutron scattering (SANS) and conductivity. The critical micellar concentration of the biocides and the size and shape of the micellar aggregates differed with variation of pendant and spacer hydrophobicity. Furthermore, the aggregation number and size of the micelles were found to vary with changing concentration and temperature. These easily synthesized biocides exhibited potent antibacterial properties against various multidrug-resistant bacteria. The optimized biocides with minimum hematotoxicity and potent antibacterial activity against methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii exhibited rapid killing kinetics against planktonic bacteria. Also, these membrane-active agents were able to eradicate preformed biofilms. The enzymatic and acidic degradation profile further offered proof of gradual degradation. Collectively, these cleavable amphiphilic biocides demonstrated excellent potency for combating the multidrug-resistant bacterial infection
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|a Journal Article
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|a Dey, Rajib
|e verfasserin
|4 aut
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|a Acharya, Yash
|e verfasserin
|4 aut
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|a Aswal, Vinod Kumar
|e verfasserin
|4 aut
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|a Haldar, Jayanta
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g (2024) vom: 07. Feb.
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|x 1520-5827
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|g year:2024
|g day:07
|g month:02
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|u http://dx.doi.org/10.1021/acs.langmuir.3c02771
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