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240206s2024 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-024-02737-z
|2 doi
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|a pubmed24n1333.xml
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|a (DE-627)NLM368045382
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|a (NLM)38315267
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Rohonczy, Jillian
|e verfasserin
|4 aut
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|a The effects of two short-chain perfluoroalkyl carboxylic acids (PFCAs) on northern leopard frog (Rana pipiens) tadpole development
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 15.03.2024
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|a Date Revised 17.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024. Crown.
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|a Short-chain perfluoroalkyl carboxylic acids (PFCAs) have been detected in the environment globally. The presence and persistence of these compounds in the environment may lead to chronic wildlife exposure. We used northern leopard frog (Rana pipiens) tadpoles to investigate the chronic toxicity and the bioconcentration of two short-chain PFCAs, perfluorobutanoic acid (PFBA) and perfluorohexanoic acid (PFHxA). We exposed Gosner stage 25 tadpoles to PFBA and PFHxA (as individual chemicals) at nominal concentrations of 0.1, 1, 10, 100, and 1000 µg/L for 43-46 days. Tadpoles exposed to 0.1 to 100 µg/L of PFBA and PFHxA had significantly higher mean snout-to-vent lengths, mean masses, and scaled mass indexes than control tadpoles. These results indicate that exposure to short-chain PFCAs influences tadpole growth. Further investigation into the mechanism(s) causing the observed changes in tadpole growth is warranted. We observed a significantly higher proportion of males in the PFBA 1 µg/L treatment group, however further histological analyses are required to confirm visual sex identification before making concrete conclusions on the effects of PFCAs on amphibian sex ratios. PFBA concentrations in tissues were higher than PFHxA concentrations; a pattern that contrasts with previously published studies using fish, suggesting potential differences between taxa in PFBA and PFHxA bioconcentration. Bioconcentration factors were <10 L/kg wet weight, indicating low bioconcentration potential in tadpoles. Our results suggest that PFBA and PFHxA may have effects at environmentally-relevant concentrations (0.1-10 µg/L) and further investigation is required before these compounds can be deemed a "safe" alternative to their long-chain counterparts
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|a Journal Article
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|a Amphibian
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|a Chronic toxicity
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|a Ecotoxicology
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|a PFAS
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|a Sublethal effect
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| 650 |
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|a Carboxylic Acids
|2 NLM
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|a perfluorohexanoic acid
|2 NLM
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| 650 |
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|a ZP34Q2220R
|2 NLM
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| 650 |
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|a Fluorocarbons
|2 NLM
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| 650 |
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|a Caproates
|2 NLM
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| 700 |
1 |
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|a Robinson, Stacey A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Forbes, Mark R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a De Silva, Amila O
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brinovcar, Cassandra
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bartlett, Adrienne J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gilroy, Ève A M
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 33(2024), 2 vom: 01. März, Seite 177-189
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:33
|g year:2024
|g number:2
|g day:01
|g month:03
|g pages:177-189
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|u http://dx.doi.org/10.1007/s10646-024-02737-z
|3 Volltext
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