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240203s2024 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.202307585
|2 doi
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|a pubmed24n1399.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Gao, Shuna
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Chlorella-Loaded Antibacterial Microneedles for Microacupuncture Oxygen Therapy of Diabetic Bacterial Infected Wounds
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 15.04.2024
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|a Date Revised 06.05.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella-loaded poly(ionic liquid)-based microneedles (PILMN-Chl) are constructed for microacupuncture oxygen and antibacterial therapy against methicillin-resistant Staphylococcus aureus (MRSA)-infected chronic diabetic wounds. The PILMN-Chl can stably and continuously produce oxygen for more than 30 h due to the photosynthesis of the loaded self-supported Chlorella. By combining the barrier penetration capabilities of microneedles, the continuous and sufficient oxygen supply of Chlorella, and the sterilization activities of PIL, the PILMN-Chl can accelerate chronic diabetic wounds in vivo by topical targeted sterilization and hypoxia relief in deep parts of wounds. Thus, the self-oxygen produced microneedles modality may provide a promising and facile therapeutic strategy for treating chronic, hypoxic, and infected diabetic wounds
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|a Journal Article
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|a Chlorella
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|a antibacterial
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|a diabetic wound
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|a hypoxia relief
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4 |
|a microneedle
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| 650 |
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|a Anti-Bacterial Agents
|2 NLM
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| 650 |
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|a Oxygen
|2 NLM
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| 650 |
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7 |
|a S88TT14065
|2 NLM
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| 700 |
1 |
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|a Rao, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Xiaowei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Qiuyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yuxuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Jiangna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Feng
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 15 vom: 30. Apr., Seite e2307585
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|g volume:36
|g year:2024
|g number:15
|g day:30
|g month:04
|g pages:e2307585
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|u http://dx.doi.org/10.1002/adma.202307585
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