Self-Disassembling and Oxygen-Generating Porphyrin-Lipoprotein Nanoparticle for Targeted Glioblastoma Resection and Enhanced Photodynamic Therapy

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 15 vom: 01. Apr., Seite e2307454
1. Verfasser:	Chen, Yaoxing (VerfasserIn)
Weitere Verfasser:	Ma, Yuxiao, Shi, Kexin, Chen, Huan, Han, Xiao, Wei, Chenxuan, Lyu, Yingqi, Huang, Yukun, Yu, Renhe, Song, Yun, Song, Qingxiang, Jiang, Jiyao, Feng, Junfeng, Lin, Yingying, Chen, Jun, Chen, Hongzhuan, Zheng, Gang, Gao, Xiaoling, Jiang, Gan
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2024
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article calcium peroxide enhanced photodynamic therapy fluorescence‐guided surgery glioblastoma‐initiating cells macropinocytosis porphyrin lipoprotein nanoparticles Porphyrins 7FRO2ENO91 Oxygen mehr... S88TT14065 Photosensitizing Agents Peroxides

Beschreibung
Zusammenfassung:	© 2024 Wiley‐VCH GmbH. The dismal prognosis for glioblastoma multiform (GBM) patients is primarily attributed to the highly invasive tumor residual that remained after surgical intervention. The development of precise intraoperative imaging and postoperative residual removal techniques will facilitate the gross total elimination of GBM. Here, a self-disassembling porphyrin lipoprotein-coated calcium peroxide nanoparticles (PLCNP) is developed to target GBM via macropinocytosis, allowing for fluorescence-guided surgery of GBM and improving photodynamic treatment (PDT) of GBM residual by alleviating hypoxia. By reducing self-quenching and enhancing lysosome escape efficiency, the incorporation of calcium peroxide (CaO2) cores in PLCNP amplifies the fluorescence intensity of porphyrin-lipid. Furthermore, the CaO2 core has diminished tumor hypoxia and improves the PDT efficacy of PLCNP, enabling low-dose PDT and reversing tumor progression induced by hypoxia aggravation following PDT. Taken together, this self-disassembling and oxygen-generating porphyrin-lipoprotein nanoparticle may serve as a promising all-in-one nanotheranostic platform for guiding precise GBM excision and empowering post-operative PDT, providing a clinically applicable strategy to combat GBM in a safe and effective manner
Beschreibung:	Date Completed 15.04.2024 Date Revised 06.05.2024 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.202307454