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240127s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202307810
|2 doi
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|a pubmed25n1225.xml
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|a eng
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|a Seong, Duhwan
|e verfasserin
|4 aut
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|a Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 19.04.2024
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|a Date Revised 19.04.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti-inflammation remains to be resolved. Herein, a sticky and strain-gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin-inspired hierarchical structure entailing strain-gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self-healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair
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|a Journal Article
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|a adhesive
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|a nerve repair
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|a neurorrhaphy
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|a self‐healing
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|a stretchable
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|a Choi, Yeonsun
|e verfasserin
|4 aut
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|a Choi, In Cheul
|e verfasserin
|4 aut
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|a Lee, Jaebeom
|e verfasserin
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|a Choi, Jae Hyuk
|e verfasserin
|4 aut
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|a Park, Ji Hun
|e verfasserin
|4 aut
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|a Nam, Jae Jun
|e verfasserin
|4 aut
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|a Ju, Jaewon
|e verfasserin
|4 aut
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|a Ryoo, Hyun Jae
|e verfasserin
|4 aut
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|a Kwak, Donghee
|e verfasserin
|4 aut
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|a Lee, Joonyeol
|e verfasserin
|4 aut
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|a Kim, Seong-Gi
|e verfasserin
|4 aut
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|a Kim, Dong Hwee
|e verfasserin
|4 aut
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|a Park, Jong Woong
|e verfasserin
|4 aut
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|a Shin, Mikyung
|e verfasserin
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|a Son, Donghee
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 16 vom: 01. Apr., Seite e2307810
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:36
|g year:2024
|g number:16
|g day:01
|g month:04
|g pages:e2307810
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|u http://dx.doi.org/10.1002/adma.202307810
|3 Volltext
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