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240114s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202311474
|2 doi
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|a pubmed24n1380.xml
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|a eng
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| 100 |
1 |
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|a Zhang, Ling-Feng
|e verfasserin
|4 aut
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| 245 |
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|a Vicious Cycle-Breaking Lipid Nanoparticles Remodeling Multicellular Crosstalk to Reverse Liver Fibrosis
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 19.04.2024
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|a Date Revised 19.04.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2024 Wiley‐VCH GmbH.
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|a During liver fibrogenesis, the reciprocal crosstalk among capillarized liver sinusoidal endothelial cells (LSECs), activated hepatic stellate cells (HSCs), and dysfunctional hepatocytes constructs a self-amplifying vicious cycle, greatly exacerbating the disease condition and weakening therapeutic effect. Limited by the malignant cellular interactions, the previous single-cell centric treatment approaches show unsatisfactory efficacy and fail to meet clinical demand. Herein, a vicious cycle-breaking strategy is proposed to target and repair pathological cells separately to terminate the malignant progression of liver fibrosis. Chondroitin sulfate-modified and vismodegib-loaded nanoparticles (CS-NPs/VDG) are designed to efficiently normalize the fenestrae phenotype of LSECs and restore HSCs to quiescent state by inhibiting Hedgehog signaling pathway. In addition, glycyrrhetinic acid-modified and silybin-loaded nanoparticles (GA-NPs/SIB) are prepared to restore hepatocytes function by relieving oxidative stress. The results show successful interruption of vicious cycle as well as distinct fibrosis resolution in two animal models through multiregulation of the pathological cells. This work not only highlights the significance of modulating cellular crosstalk but also provides a promising avenue for developing antifibrotic regimens
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|a Journal Article
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|a hepatic stellate cell
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| 650 |
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4 |
|a hepatocyte
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| 650 |
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4 |
|a liver fibrosis
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| 650 |
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4 |
|a liver sinusoidal endothelial cell
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| 650 |
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4 |
|a remodel multicellular crosstalk
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| 650 |
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|a Lipid Nanoparticles
|2 NLM
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| 650 |
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7 |
|a Hedgehog Proteins
|2 NLM
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| 650 |
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|a Liposomes
|2 NLM
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| 700 |
1 |
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|a Deng, Wen-Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Qing-Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Jiao-Jiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Tian-Jiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xing, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Hu-Lin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 16 vom: 09. Apr., Seite e2311474
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:36
|g year:2024
|g number:16
|g day:09
|g month:04
|g pages:e2311474
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| 856 |
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|u http://dx.doi.org/10.1002/adma.202311474
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