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240114s2024 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erae007
|2 doi
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|a pubmed24n1577.xml
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|a (DE-627)NLM366809709
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|a (NLM)38190348
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Xu, Chaoqun
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a PlantC2U
|b deep learning of cross-species sequence landscapes predicts plastid C-to-U RNA editing in plants
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|c 2024
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 16.04.2024
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| 500 |
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|a Date Revised 23.10.2024
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a © The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a In plants, C-to-U RNA editing mainly occurs in plastid and mitochondrial transcripts, which contributes to a complex transcriptional regulatory network. More evidence reveals that RNA editing plays critical roles in plant growth and development. However, accurate detection of RNA editing sites using transcriptome sequencing data alone is still challenging. In the present study, we develop PlantC2U, which is a convolutional neural network, to predict plastid C-to-U RNA editing based on the genomic sequence. PlantC2U achieves >95% sensitivity and 99% specificity, which outperforms the PREPACT tool, random forests, and support vector machines. PlantC2U not only further checks RNA editing sites from transcriptome data to reduce possible false positives, but also assesses the effect of different mutations on C-to-U RNA editing based on the flanking sequences. Moreover, we found the patterns of tissue-specific RNA editing in the mangrove plant Kandelia obovata, and observed reduced C-to-U RNA editing rates in the cold stress response of K. obovata, suggesting their potential regulatory roles in plant stress adaptation. In addition, we present RNAeditDB, available online at https://jasonxu.shinyapps.io/RNAeditDB/. Together, PlantC2U and RNAeditDB will help researchers explore the RNA editing events in plants and thus will be of broad utility for the plant research community
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a C-to-U RNA editing
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| 650 |
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4 |
|a R/Shiny
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| 650 |
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4 |
|a RNA-seq
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| 650 |
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4 |
|a deep learning
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| 650 |
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4 |
|a mangrove
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| 650 |
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4 |
|a plastid
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| 650 |
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7 |
|a RNA, Plant
|2 NLM
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| 700 |
1 |
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|a Li, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Ling-Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Ze-Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Shi-Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Lu-Dan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Hai-Lei
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 75(2024), 8 vom: 15. Apr., Seite 2266-2279
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
1 |
8 |
|g volume:75
|g year:2024
|g number:8
|g day:15
|g month:04
|g pages:2266-2279
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| 856 |
4 |
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|u http://dx.doi.org/10.1093/jxb/erae007
|3 Volltext
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