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240114s2024 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2024.109891
|2 doi
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|a eng
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|a Maier, Felix I
|e verfasserin
|4 aut
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|a Chemotherapy for a secondary malignancy nearly restores complete chimerism in an SCID-patient after HSCT
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 29.01.2024
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|a Date Revised 10.04.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
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|a For patients with inborn errors of immunity (IEI) and other inborn diseases, mixed donor chimerism is a well-accepted outcome of hematopoietic stem cell transplantation (HSCT). Cytoreductive chemotherapy for a secondary malignancy is a potential challenge for the stability of the graft function after HSCT. We report on a boy with X-SCID who developed Ewing sarcoma ten years after HSCT which was successfully treated with cytoreductive chemotherapy, surgery and local radiation. Surprisingly, this treatment had a positive impact on mixed chimerism with an increase of donor-cell proportions from 40% for neutrophils and 75% for non-T-mononuclear cells (MNCs) to >90% for both. T-cell counts remained stable with 100% of donor origin. This is -to our knowledge- the first report on the impact of cytoreductive chemotherapy on post-HSCT mixed chimerism and provides an important first impression for future patients
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|a Journal Article
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|a Hematopoietic stem cell transplantation
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|a Inborn errors of immunity
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| 650 |
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|a Mixed Chimerism
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| 650 |
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|a Secondary malignancy
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|a Schulz, Ansgar
|e verfasserin
|4 aut
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|a Furlan, Ingrid
|e verfasserin
|4 aut
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|a Felgentreff, Kerstin
|e verfasserin
|4 aut
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|a Jacobsen, Eva-Maria
|e verfasserin
|4 aut
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|a Sirin, Mehtap
|e verfasserin
|4 aut
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|a Schwarz, Klaus
|e verfasserin
|4 aut
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|a Pannicke, Ulrich
|e verfasserin
|4 aut
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| 700 |
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|a Stursberg, Jana
|e verfasserin
|4 aut
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| 700 |
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|a Debatin, Klaus-Michael
|e verfasserin
|4 aut
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| 700 |
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|a Hönig, Manfred
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 259(2024) vom: 10. Feb., Seite 109891
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|x 1521-7035
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|g volume:259
|g year:2024
|g day:10
|g month:02
|g pages:109891
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