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240108s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c03049
|2 doi
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|a eng
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|a Konwar, Korobi
|e verfasserin
|4 aut
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|a Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe2O3ZnFe2O4
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 23.01.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a The potential application of magnetic nanosystems as magnetic resonance imaging (MRI) contrast agents has been thoroughly investigated. This work seeks to attain robust MRI-contrast efficiency by designing an interacting landscape of a bimagnetic ensemble of zinc ferrite nanorods and maghemite nanoparticles, γ-Fe2O3ZnFe2O4. Because of competing spin clusters and structural anisotropy triggered by isotropic γ-Fe2O3 and anisotropic ZnFe2O4, γ-Fe2O3@ZnFe2O4 undergoes the evolution of cluster spin-glass state as evident from the critical slowing down law. Such interacting γ-Fe2O3@ZnFe2O4 with spin flipping of 1.2 × 10-8 s and energy barrier of 8.2 × 10-14 erg reflects enhanced MRI-contrast signal. Additionally, γ-Fe2O3@ZnFe2O4 is cell-viable to noncancerous HEK 293 cell-line and shows no pro-tumorigenic activity as observed in MDA-MB-231, an extremely aggressive triple-negative breast cancer cell line. As a result, γ-Fe2O3@ZnFe2O4 is a feasible option for an MRI-contrast agent having longitudinal relaxivity, r1, of 0.46 s-1mM-1 and transverse relaxivity, r2, of 15.94 s-1mM-1, together with r2/r1 of 34.65 at 1.41 T up to a modest metal concentration of 0.1 mM. Hence, this study addresses an interacting isotropic/anisotropic framework with faster water proton decay in MR-relaxivity resulting in phantom signal amplification
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|a Journal Article
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|a Kaushik, Som Datta
|e verfasserin
|4 aut
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|a Babu, Peram Delli
|e verfasserin
|4 aut
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|a Chaturvedi, Anamika
|e verfasserin
|4 aut
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|a Kumar, Dinesh
|e verfasserin
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|a Chakraborty, Rituraj
|e verfasserin
|4 aut
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|a Mukhopadhyay, Rupak
|e verfasserin
|4 aut
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|a Sharma, Pooja
|e verfasserin
|4 aut
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|a Lodha, Saurabh
|e verfasserin
|4 aut
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|a Sen, Debasis
|e verfasserin
|4 aut
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|a Deb, Pritam
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 40(2024), 3 vom: 23. Jan., Seite 1793-1803
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:40
|g year:2024
|g number:3
|g day:23
|g month:01
|g pages:1793-1803
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|u http://dx.doi.org/10.1021/acs.langmuir.3c03049
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