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240108s2024 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.3c02817
|2 doi
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|a eng
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| 100 |
1 |
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|a Wang, Min
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Molecular Modeling of the Fluorination Effect on the Penetration of Nanoparticles across Lipid Bilayers
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| 264 |
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 17.01.2024
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|a Date Revised 15.02.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The fluorinated decorations have recently been widely used in many biomedical applications. However, the potential mechanism of the fluorination effect on the cellular delivery of nanoparticles (NPs) still remains elusive. In this work, we systemically explore the penetration of a perfluoro-octanethiol-coated gold NP (PF-Au NP) and, for comparison, an octanethiol-coated gold NP (OT-Au NP) across lipid bilayers. We also investigated the effect of these two types of NPs on the properties of lipid bilayers. Our findings indicate that the lipid type and the surface tension of the lipid bilayer significantly impact the penetration capabilities of the fluorinated gold NP. By examining the distribution of ligands on the surface of the two types of NPs in water and during the penetration process, we unveil their distinct penetration characteristics. Specifically, the PF-Au NP exhibits amphiphobic behavior (both hydrophobic and lipophobic), while the OT-Au NP exhibits solely hydrophobic characteristics. Finally, we observe that the penetration capabilities can be increased by adjusting the degree of fluorination of the ligands on the NP surface. Overall, this study provides useful physical insights into the unique properties of the fluorinated decorations in NP permeation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lipid Bilayers
|2 NLM
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|a Gold
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|a 7440-57-5
|2 NLM
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|a Ligands
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| 700 |
1 |
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|a Ni, Song-Di
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yin, Yue-Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Yu-Qiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, Hong-Ming
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 40(2024), 2 vom: 16. Jan., Seite 1295-1304
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:40
|g year:2024
|g number:2
|g day:16
|g month:01
|g pages:1295-1304
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|u http://dx.doi.org/10.1021/acs.langmuir.3c02817
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