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|a 10.3760/cma.j.cn112140-20231021-00309
|2 doi
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Zhang, H S
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Clinical analysis of 11 cases multisystem inflammatory syndrome associated with SARS-CoV-2 Omicron variant infection in children
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 01.01.2024
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|a Date Revised 01.01.2024
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|a published: Print
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|a Citation Status MEDLINE
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|a Objective: To explore the clinical characteristics, diagnosis, treatment, and follow-up of multisystem inflammatory syndrome in children (MIS-C) related to SARS-CoV-2 Omicron variant infection. Methods: A retrospective analysis was conducted on clinical data of 11 children with MIS-C, who were admitted to the Department of Pediatrics of Peking University First Hospital from December 2022 to January 2023. Clinical characteristics, treatment, and follow-up of MIS-C were summarized in this study. Results: The 11 cases contained 7 boys and 4 girls, with an age of 4.4 (2.0, 5.5) years on admission. All the patients had fever, with a duration of 7(5, 9) days. Other clinical manifestations included rash in 7 cases, conjunctival hyperemia in 5 cases, red lips and raspberry tongue in 3 cases, lymphadenopathy in 3 cases, and swollen fingers and toes in 2 cases. There were 8 cases of digestive symptoms, 8 cases of respiratory symptoms, and 3 cases of nervous system symptoms. Eight patients had multi-system injuries, and one of them had shock presentation. All 11 patients were infected with SARS-CoV-2 Omicron BF.7 variant. The laboratory examination results showed that all cases had elevated inflammatory indicators, abnormal coagulation function and myocardial damage. Six patients had elevated white blood cell counts, 5 cases had liver function abnormalities, 3 cases had kidney function abnormalities, and 8 cases had coronary artery involvement. All 11 patients received anti-infection treatment, of which 3 cases received only 2 g/kg intravenous immunoglobulin (IVIG), while the remaining 8 cases received a combination of IVIG and 2 mg/(kg·d) methylprednisolone. Among the 8 cases with coronary artery disease, 6 cases received low molecular weight heparin anticoagulation therapy. All patients were followed up in 2 weeks after being discharged, and their inflammatory markers had returned to normal by that time. The 8 cases with coronary artery disease and 3 cases with pneumonia showed significant improvement or back to normal at the 4-week follow-up. All patients had no new complications or comorbidities during follow-up of more than 3 months. Conclusions: MIS-C may present with Kawasaki disease-like symptoms, with or without gastrointestinal, neurological, or respiratory symptoms. Elevated inflammatory markers, abnormal coagulation function, and cardiac injury contribute to the diagnosis of MIS-C. IVIG and methylprednisolone were the primary treatments for MIS-C, and a favorable short-term prognosis was observed during a follow-up period of more than 3 months
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|a English Abstract
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|a Journal Article
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|a Immunoglobulins, Intravenous
|2 NLM
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| 650 |
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|a Methylprednisolone
|2 NLM
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| 650 |
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|a X4W7ZR7023
|2 NLM
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| 700 |
1 |
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|a Chang, X T
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, P H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, D Y
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ge, G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ding, W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hu, Z W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, G F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Y W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ye, L P
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 62(2024), 1 vom: 02. Jan., Seite 55-59
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
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|g volume:62
|g year:2024
|g number:1
|g day:02
|g month:01
|g pages:55-59
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|u http://dx.doi.org/10.3760/cma.j.cn112140-20231021-00309
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