A Fiber Sensor for Long-Term Monitoring of Extracellular Potassium Ion Fluctuations in Chronic Neuropsychiatric Diseases

A Fiber Sensor for Long-Term Monitoring of Extracellular Potassium Ion Fluctuations in Chronic Neuropsychiatric Diseases

© 2023 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 13 vom: 24. März, Seite e2309862
1. Verfasser: Wang, Jiajia (VerfasserIn)
Weitere Verfasser: Wang, Liyuan, Yang, Yiqing, Li, HongJian, Huang, Xinlin, Liu, Ziwei, Yu, Sihui, Tang, Chengqiang, Chen, Jiawei, Shi, Xiang, Li, Wenjun, Chen, Peining, Tong, Qi, Yu, Hongbo, Sun, Xuemei, Peng, Huisheng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article chronic neuropsychiatric diseases depression fiber electronics implantable sensor potassium ion Potassium RWP5GA015D Ions
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520 |a The extracellular potassium ion concentration in the brain exerts a significant influence on cellular excitability and intercellular communication. Perturbations in the extracellular potassium ion level are closely correlated with various chronic neuropsychiatric disorders including depression. However, a critical gap persists in performing real-time and long-term monitoring of extracellular potassium ions, which is necessary for comprehensive profiling of chronic neuropsychiatric diseases. Here, a fiber potassium ion sensor (FKS) that consists of a soft conductive fiber with a rough surface and a hydrophobic-treated transduction layer interfaced with a potassium ion-selective membrane is found to solve this problem. The FKS demonstrates stable interfaces between its distinct functional layers in an aqueous environment, conferring an exceptional stability of 6 months in vivo, in stark contrast to previous reports with working durations from hours to days. Upon implantation into the mouse brain, the FKS enables effective monitoring of extracellular potassium ion dynamics under diverse physiological states including anesthesia, forced swimming, and tail suspension. Using this FKS, tracking of extracellular potassium ion fluctuations that align with behaviors associated with the progression of depression over months is achieved, demonstrating its usability in studying chronic neuropsychiatric disorders from a new biochemical perspective 
650 4 |a Journal Article 
650 4 |a chronic neuropsychiatric diseases 
650 4 |a depression 
650 4 |a fiber electronics 
650 4 |a implantable sensor 
650 4 |a potassium ion 
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700 1 |a Wang, Liyuan  |e verfasserin  |4 aut 
700 1 |a Yang, Yiqing  |e verfasserin  |4 aut 
700 1 |a Li, HongJian  |e verfasserin  |4 aut 
700 1 |a Huang, Xinlin  |e verfasserin  |4 aut 
700 1 |a Liu, Ziwei  |e verfasserin  |4 aut 
700 1 |a Yu, Sihui  |e verfasserin  |4 aut 
700 1 |a Tang, Chengqiang  |e verfasserin  |4 aut 
700 1 |a Chen, Jiawei  |e verfasserin  |4 aut 
700 1 |a Shi, Xiang  |e verfasserin  |4 aut 
700 1 |a Li, Wenjun  |e verfasserin  |4 aut 
700 1 |a Chen, Peining  |e verfasserin  |4 aut 
700 1 |a Tong, Qi  |e verfasserin  |4 aut 
700 1 |a Yu, Hongbo  |e verfasserin  |4 aut 
700 1 |a Sun, Xuemei  |e verfasserin  |4 aut 
700 1 |a Peng, Huisheng  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 36(2024), 13 vom: 24. März, Seite e2309862  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnas 
773 1 8 |g volume:36  |g year:2024  |g number:13  |g day:24  |g month:03  |g pages:e2309862 
856 4 0 |u http://dx.doi.org/10.1002/adma.202309862  |3 Volltext 
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