Point-Of-Care Ultra-Portable Single-Molecule Bioassays for One-Health

Point-Of-Care Ultra-Portable Single-Molecule Bioassays for One-Health

© 2023 The Authors. Advanced Materials published by Wiley‐VCH GmbH.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 13 vom: 12. März, Seite e2309705
Auteur principal: Macchia, Eleonora (Auteur)
Autres auteurs: Torricelli, Fabrizio, Caputo, Mariapia, Sarcina, Lucia, Scandurra, Cecilia, Bollella, Paolo, Catacchio, Michele, Piscitelli, Matteo, Di Franco, Cinzia, Scamarcio, Gaetano, Torsi, Luisa
Format: Article en ligne
Langue:English
Publié: 2024
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article Review Single‐molecule with a large transistor(SiMoT) clustered regularly interspaced short palindromic repeats/Cas (CRISPR/Cas) lateral flow strip test one health point of care testing (POCT) preventing healthcare RNA 63231-63-0
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520 |a Screening asymptomatic organisms (humans, animals, plants) with a high-diagnostic accuracy using point-of-care-testing (POCT) technologies, though still visionary holds great potential. Convenient surveillance requires easy-to-use, cost-effective, ultra-portable but highly reliable, in-vitro-diagnostic devices that are ready for use wherever they are needed. Currently, there are not yet such devices available on the market, but there are a couple more promising technologies developed at readiness-level 5: the Clustered-Regularly-Interspaced-Short-Palindromic-Repeats (CRISPR) lateral-flow-strip tests and the Single-Molecule-with-a-large-Transistor (SiMoT) bioelectronic palmar devices. They both hold key features delineated by the World-Health-Organization for POCT systems and an occurrence of false-positive and false-negative errors <1-5% resulting in diagnostic-selectivity and sensitivity >95-99%, while limit-of-detections are of few markers. CRISPR-strip is a molecular assay that, can detect down to few copies of DNA/RNA markers in blood while SiMoT immunometric and molecular test can detect down to a single oligonucleotide, protein marker, or pathogens in 0.1mL of blood, saliva, and olive-sap. These technologies can prospectively enable the systematic and reliable surveillance of asymptomatic ones prior to worsening/proliferation of illnesses allowing for timely diagnosis and swift prognosis. This could establish a proactive healthcare ecosystem that results in effective treatments for all living organisms generating diffuse and well-being at efficient costs 
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650 4 |a Review 
650 4 |a Single‐molecule with a large transistor(SiMoT) 
650 4 |a clustered regularly interspaced short palindromic repeats/Cas (CRISPR/Cas) 
650 4 |a lateral flow strip test 
650 4 |a one health 
650 4 |a point of care testing (POCT) 
650 4 |a preventing healthcare 
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650 7 |a 63231-63-0  |2 NLM 
700 1 |a Torricelli, Fabrizio  |e verfasserin  |4 aut 
700 1 |a Caputo, Mariapia  |e verfasserin  |4 aut 
700 1 |a Sarcina, Lucia  |e verfasserin  |4 aut 
700 1 |a Scandurra, Cecilia  |e verfasserin  |4 aut 
700 1 |a Bollella, Paolo  |e verfasserin  |4 aut 
700 1 |a Catacchio, Michele  |e verfasserin  |4 aut 
700 1 |a Piscitelli, Matteo  |e verfasserin  |4 aut 
700 1 |a Di Franco, Cinzia  |e verfasserin  |4 aut 
700 1 |a Scamarcio, Gaetano  |e verfasserin  |4 aut 
700 1 |a Torsi, Luisa  |e verfasserin  |4 aut 
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773 1 8 |g volume:36  |g year:2024  |g number:13  |g day:12  |g month:03  |g pages:e2309705 
856 4 0 |u http://dx.doi.org/10.1002/adma.202309705  |3 Volltext 
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