Harmonizing Thickness and Permeability in Bone Tissue Engineering A Novel Silk Fibroin Membrane Inspired by Spider Silk Dynamics

Harmonizing Thickness and Permeability in Bone Tissue Engineering : A Novel Silk Fibroin Membrane Inspired by Spider Silk Dynamics

© 2023 Wiley‐VCH GmbH.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 36(2024), 13 vom: 14. März, Seite e2310697
1. Verfasser: Chen, Wenze (VerfasserIn)
Weitere Verfasser: Liu, Keyin, Liao, Xiaoyu, Wu, Jing, Chen, Lu, Yang, Zihan, Wang, Xiping, Liao, Yinxiu, Fu, Guiqiang, Yang, Xiaonian, Wang, Zishuo, Qu, Guanlin, Wang, Li, Zhou, Yuqiong, Zhang, ZhiYuan, Yang, Chi, Ni, Siyuan, Zheng, Jisi, Tao, Tiger H, Zou, Duohong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2024
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article GBR application anti‐infection bilayer membrane liquid transport silk fibroin Silk Fibroins 9007-76-5 Water 059QF0KO0R
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520 |a Guided bone regeneration gathers significant interest in the realm of bone tissue engineering; however, the interplay between membrane thickness and permeability continues to pose a challenge that can be addressed by the water-collecting mechanism of spider silk, where water droplets efficiently move from smooth filaments to rough conical nodules. Inspired by the natural design of spider silk, an innovative silk fibroin membrane is developed featuring directional fluid transportation via harmoniously integrating a smooth, dense layer with a rough, loose layer; conical microchannels are engineered in the smooth and compact layer. Consequently, double-layered membranes with cone-shaped microporous passageways (CSMP-DSF membrane) are designed for in situ bone repair. Through extensive in vitro testing, it is noted that the CSMP-DSF membrane guides liquid flow from the compact layer's surface to the loose layer, enabling rapid diffusion. Remarkably, the CSMP-DSF membrane demonstrates superior mechanical properties and resistance to bacterial adhesion. When applied in vivo, the CSMP-DSF membrane achieves results on par with the commercial Bio-Gide collagen membranes. This innovative integration of a cross-thickness wetting gradient structure offers a novel solution, harmonizing the often-conflicting requirements of material transport, mechanical strength, and barrier effectiveness, while also addressing issues related to tissue engineering scaffold perfusion 
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650 4 |a anti‐infection 
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650 4 |a liquid transport 
650 4 |a silk fibroin 
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700 1 |a Liu, Keyin  |e verfasserin  |4 aut 
700 1 |a Liao, Xiaoyu  |e verfasserin  |4 aut 
700 1 |a Wu, Jing  |e verfasserin  |4 aut 
700 1 |a Chen, Lu  |e verfasserin  |4 aut 
700 1 |a Yang, Zihan  |e verfasserin  |4 aut 
700 1 |a Wang, Xiping  |e verfasserin  |4 aut 
700 1 |a Liao, Yinxiu  |e verfasserin  |4 aut 
700 1 |a Fu, Guiqiang  |e verfasserin  |4 aut 
700 1 |a Yang, Xiaonian  |e verfasserin  |4 aut 
700 1 |a Wang, Zishuo  |e verfasserin  |4 aut 
700 1 |a Qu, Guanlin  |e verfasserin  |4 aut 
700 1 |a Wang, Li  |e verfasserin  |4 aut 
700 1 |a Zhou, Yuqiong  |e verfasserin  |4 aut 
700 1 |a Zhang, ZhiYuan  |e verfasserin  |4 aut 
700 1 |a Yang, Chi  |e verfasserin  |4 aut 
700 1 |a Ni, Siyuan  |e verfasserin  |4 aut 
700 1 |a Zheng, Jisi  |e verfasserin  |4 aut 
700 1 |a Tao, Tiger H  |e verfasserin  |4 aut 
700 1 |a Zou, Duohong  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 36(2024), 13 vom: 14. März, Seite e2310697  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:36  |g year:2024  |g number:13  |g day:14  |g month:03  |g pages:e2310697 
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