|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM365936359 |
| 003 |
DE-627 |
| 005 |
20250305140027.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231227s2024 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.202309839
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n1219.xml
|
| 035 |
|
|
|a (DE-627)NLM365936359
|
| 035 |
|
|
|a (NLM)38102944
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Yin, Hao
|e verfasserin
|4 aut
|
| 245 |
1 |
2 |
|a A CTL-Inspired Killing System Using Ultralow-Dose Chemical-Drugs to Induce a Pyroptosis-Mediated Antitumor Immune Function
|
| 264 |
|
1 |
|c 2024
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 29.03.2024
|
| 500 |
|
|
|a Date Revised 29.03.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2023 Wiley‐VCH GmbH.
|
| 520 |
|
|
|a A Cytotoxic T lymphocyte-inspired system capable of using ultralow-dose chemical drugs to manipulate cell death is needed to investigate the antitumor immunotherapy. Recent studies reveal pyroptosis promotes antitumor immune function. However, high-dose chemotherapy leads to cytokine release syndrome by pyroptosis. Therefore, pyroptosis-inducing ultralow-dose chemotherapy is potential in preclinical and clinical research, but its efficacy, safety, and the antitumor immune responses are not clear. Here, a near-infrared light controllable killing system (BIK system) is established by which ultralow-dose doxorubicin can be spatiotemporally transported to tumor cells and mediate efficient pyroptosis. This BIK system reduces total drug consumption to less than one-thirtieth the common dose in vitro. Moreover, this BIK system exhibited good tumor targeting and tumor penetration. This system is applied for pyroptosis-induced antitumor therapies, which shows less than ≈25 µg kg-1 doxorubicin is sufficient for tumor regression with negligible injuries to major organs. The antitumor immune function are proven to correlate with the impressive efficacy of pyroptosis-inducing ultralow-dose chemotherapy. This study provides new insights into the design of nanoassisted systems for activating the antitumor immunity by microstimulation; the application of the BIK system suggests that ultralow-dose chemotherapy is sufficient for inducing a robust pyroptosis-mediated antitumor immunity
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a antitumor immunotherapy
|
| 650 |
|
4 |
|a bioinspired killing system
|
| 650 |
|
4 |
|a pyroptosis
|
| 650 |
|
4 |
|a ultralow‐dose drugs
|
| 650 |
|
7 |
|a Doxorubicin
|2 NLM
|
| 650 |
|
7 |
|a 80168379AG
|2 NLM
|
| 700 |
1 |
|
|a Xie, Congying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zuo, Zhigui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Xie, Danli
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Qinyang
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 13 vom: 01. März, Seite e2309839
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
|
| 773 |
1 |
8 |
|g volume:36
|g year:2024
|g number:13
|g day:01
|g month:03
|g pages:e2309839
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.202309839
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 36
|j 2024
|e 13
|b 01
|c 03
|h e2309839
|