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231227s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202312024
|2 doi
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|a pubmed24n1355.xml
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|a (DE-627)NLM365924997
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|a (NLM)38101802
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Xu, Bolong
|e verfasserin
|4 aut
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|a Engineering Atomically Dispersed Cu-N1S2 Sites via Chemical Vapor Deposition to Boost Enzyme-Like Activity for Efficient Tumor Therapy
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 29.03.2024
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|a Date Revised 29.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley‐VCH GmbH.
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|a Single-atom nanozymes (SAzymes), with well-defined and uniform atomic structures, are an emerging type of natural enzyme mimics. Currently, it is important but challenging to rationally design high-performance SAzymes and deeply reveal the interaction mechanism between SAzymes and substrate molecules. Herein, this work reports the controllable fabrication of a unique Cu-N1S2-centred SAzyme (Cu-N/S-C) via a chemical vapor deposition-based sulfur-engineering strategy. Benefiting from the optimized geometric and electronic structures of single-atom sites, Cu-N/S-C SAzyme shows boosted enzyme-like activity, especially in catalase-like activity, with a 13.8-fold increase in the affinity to hydrogen peroxide (H2O2) substrate and a 65.2-fold increase in the catalytic efficiency when compared to Cu-N-C SAzyme with Cu-N3 sites. Further theoretical studies reveal that the increased electron density around single-atom Cu is achieved through electron redistribution, and the efficient charge transfer between Cu-N/S-C and H2O2 is demonstrated to be more beneficial for the adsorption and activation of H2O2. The as-designed Cu-N/S-C SAzyme possesses an excellent antitumor effect through the synergy of catalytic therapy and oxygen-dependent phototherapy. This study provides a strategy for the rational design of SAzymes, and the proposed electron redistribution and charge transfer mechanism will help to understand the coordination environment effect of single-atom metal sites on H2O2-mediated enzyme-like catalytic processes
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|a Journal Article
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|a coordination environment
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|a enzyme‐like activity
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|a single‐atom nanozyme
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|a sulfur‐engineering
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|a tumor catalytic therapy
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|a Hydrogen Peroxide
|2 NLM
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|a BBX060AN9V
|2 NLM
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| 650 |
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|a Gases
|2 NLM
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| 700 |
1 |
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|a Li, Shanshan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Along
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, You
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Mengxue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Haokun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Lirong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shi, Rui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Huiyu
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 13 vom: 20. März, Seite e2312024
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:36
|g year:2024
|g number:13
|g day:20
|g month:03
|g pages:e2312024
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|u http://dx.doi.org/10.1002/adma.202312024
|3 Volltext
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