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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202304333
|2 doi
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|a pubmed24n1330.xml
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|a (NLM)38096399
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|a DE-627
|b ger
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Shin, Min Jun
|e verfasserin
|4 aut
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| 245 |
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|a Inflammation-Targeting Mesenchymal Stem Cells Combined with Photothermal Treatment Attenuate Severe Joint Inflammation
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|c 2024
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 15.03.2024
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|a Date Revised 15.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Current clinical therapeutic efficacy for the treatment of osteo- and rheumatoid-arthritis is obviously limited. Although mesenchymal stem cells (MSCs) are considered as a source of promising regenerative therapy, un-modified or genetically engineered MSCs injected in vivo restrict their clinical utility because of the low drug efficacy and unpredicted side effect, respectively. Herein, a strategy to enhance the migration efficacy of MSCs to inflamed joints via an inflammation-mediated education process is demonstrated. To reinforce the limited anti-inflammatory activity of MSCs, gold nanostar loaded with triamcinolone is conjugated to MSC. Furthermore, near-infrared laser-assisted photothermal therapy (PTT) induced by gold nanostar significantly elevates the anti-inflammatory efficacy of the developed drugs, even in advanced stage arthritis model. An immunological regulation mechanism study of PTT is first suggested in this study; the expression of the interleukin 22 receptor, implicated in the pathogenesis of arthritis, is downregulated in T lymphocytes by PTT, and Th17 differentiation from naïve CD4 T cell is inhibited. Collectively, inflammation-targeting MSCs conjugated with triamcinolone-loaded gold nanostar (Edu-MSCs-AuS-TA) promote the repolarization of macrophages and decrease neutrophil recruitment in joints. In addition, Edu-MSCs-AuS-TA significantly alleviate arthritis-associated pain, improve general locomotor activity, and more importantly, induce cartilage regeneration even for severe stages of arthritis model
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|a Journal Article
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|a arthritis
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|a inflammation-educated mesenchymal stem cells
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|a membrane conjugations
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|a mesenchymal stem cells
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|a migration abilities
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|a photothermal therapies
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| 650 |
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|a Triamcinolone
|2 NLM
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| 650 |
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|a 1ZK20VI6TY
|2 NLM
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| 650 |
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|a Anti-Inflammatory Agents
|2 NLM
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|a Gold
|2 NLM
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| 650 |
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|a 7440-57-5
|2 NLM
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| 700 |
1 |
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|a Park, Jun-Young
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Park, Jun Young
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lim, Su Hyun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lim, Hyoungsub
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Choi, Jin Kyeong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Park, Chul-Kyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, Youn Joo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Khang, Dongwoo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 11 vom: 01. März, Seite e2304333
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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|g volume:36
|g year:2024
|g number:11
|g day:01
|g month:03
|g pages:e2304333
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|u http://dx.doi.org/10.1002/adma.202304333
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