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|a 10.1002/adma.202309452
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|a eng
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| 100 |
1 |
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|a Li, Dan
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Ultrasensitive NIR-II Ratiometric Nanothermometers for 3D In Vivo Thermal Imaging
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|c 2024
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| 336 |
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|a Text
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|a ƒaComputermedien
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|a Date Completed 15.03.2024
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|a Date Revised 15.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 Wiley-VCH GmbH.
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|a Luminescent nanothermometry, particularly the one based on ratiometric, has sparked intense research for non-invasive in vivo or intracellular temperature mapping, empowering their uses as diagnosis tools in biomedicine. However, ratiometric detection still suffers from biased sensing induced by wavelength-dependent tissue absorption and scattering, low thermal sensitivity (Sr ), and lack of imaging depth information. Herein, this work constructs an ultrasensitive NIR-II ratiometric nanothermometer with self-calibrating ability for 3D in vivo thermographic imaging, in which temperature-insensitive lanthanide nanocrystals and strongly temperature-quenched Ag2 S quantum dots are co-assembled to form a hybrid nanocomposite material. Precise control over the amount ratio between two sub-materials enables the manipulation of heat-activated back energy transfer from Ag2 S to Yb3+ in lanthanide nanoparticles, thereby rendering Sr up to 7.8% °C-1 at 43.5 °C, and higher than 6.5% °C-1 over the entire physiological temperature range. Moreover, the luminescence intensity ratio between two separated spectral regions within the narrow Yb3+ emission peak is used to determine the depth information of nanothermometers in living mice and correct the effect of tissue depth on 2D thermographic imaging, and therefore allows a proof-of-concept demonstration of accurate 3D in vivo thermographic imaging, constituting a solid step toward the development of advanced ratiometric nanothermometry for biological applications
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|a Journal Article
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|a 3D thermographic imaging
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| 650 |
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|a NIR-II
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|a ratiometric luminescent nanothermometry
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| 650 |
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4 |
|a self-calibrating program
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| 650 |
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4 |
|a thermal sensitivity
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| 650 |
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7 |
|a Lanthanoid Series Elements
|2 NLM
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| 700 |
1 |
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|a Jia, Mochen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jia, Tao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Guanying
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 11 vom: 01. März, Seite e2309452
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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|g volume:36
|g year:2024
|g number:11
|g day:01
|g month:03
|g pages:e2309452
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|u http://dx.doi.org/10.1002/adma.202309452
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