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231226s2024 xx |||||o 00| ||eng c |
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|a 10.1002/adma.202310476
|2 doi
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|a pubmed25n1218.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Han, Jin
|e verfasserin
|4 aut
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| 245 |
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|a Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response
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|c 2024
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 25.10.2024
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|a Date Revised 25.10.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2023 The Authors. Advanced Materials published by Wiley‐VCH GmbH.
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|a Aging is associated with immunological changes that compromise response to infections and vaccines, exacerbate inflammatory diseases and can potentially mitigate tissue repair. Even so, age-related changes to the immune response to tissue damage and regenerative medicine therapies remain unknown. Here, it is characterized how aging induces changes in immunological signatures that inhibit tissue repair and therapeutic response to a clinical regenerative biological scaffold derived from extracellular matrix. Signatures of inflammation and interleukin (IL)-17 signaling increased with injury and treatment both locally and regionally in aged animals, and computational analysis uncovered age-associated senescent-T cell communication that promotes type 3 immunity in T cells. Local inhibition of type 3 immune activation using IL17-neutralizing antibodies improves healing and restores therapeutic response to the regenerative biomaterial, promoting muscle repair in older animals. These results provide insights into tissue immune dysregulation that occurs with aging that can be targeted to rejuvenate repair
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|a Journal Article
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|a aging
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|a biomaterials
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|a senescence
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|a tissue engineering
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|a Biocompatible Materials
|2 NLM
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|a Interleukin-17
|2 NLM
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|a Cherry, Christopher
|e verfasserin
|4 aut
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|a Mejías, Joscelyn C
|e verfasserin
|4 aut
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|a Krishnan, Kavita
|e verfasserin
|4 aut
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|a Ruta, Anna
|e verfasserin
|4 aut
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|a Maestas, David R
|c Jr
|e verfasserin
|4 aut
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|a Peña, Alexis N
|e verfasserin
|4 aut
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|a Nguyen, Helen Hieu
|e verfasserin
|4 aut
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|a Nagaraj, Sushma
|e verfasserin
|4 aut
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|a Yang, Brenda
|e verfasserin
|4 aut
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|a Gray-Gaillard, Elise F
|e verfasserin
|4 aut
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|a Rutkowski, Natalie
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|a Browne, Maria
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|4 aut
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|a Tam, Ada J
|e verfasserin
|4 aut
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|a Fertig, Elana J
|e verfasserin
|4 aut
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|a Housseau, Franck
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|4 aut
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|a Ganguly, Sudipto
|e verfasserin
|4 aut
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|a Moore, Erika M
|e verfasserin
|4 aut
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|a Pardoll, Drew M
|e verfasserin
|4 aut
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|a Elisseeff, Jennifer H
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 36(2024), 43 vom: 12. Okt., Seite e2310476
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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|g volume:36
|g year:2024
|g number:43
|g day:12
|g month:10
|g pages:e2310476
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|u http://dx.doi.org/10.1002/adma.202310476
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